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Multimodality endoscopic imaging technology for visualization of layered architecture and vasculature

Li, Yan and Chen, Zhongping (2019) Multimodality endoscopic imaging technology for visualization of layered architecture and vasculature. In: Third International Conference on Photonics and Optical Engineering. Proceedings of SPIE. No.11052. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 110520B. ISBN 9781510627796. https://resolver.caltech.edu/CaltechAUTHORS:20190506-135609015

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Abstract

Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT), near infrared (NIR) fluorescence, photoacoustic (PA), and ultrasound (US) have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal (GI) tract. Here, we developed two multimodality imaging systems which are integrated PA/US and integrated OCT/NIR fluorescence which can obtain layered architecture and vasculature simultaneously. In vivo imaging of rectum wall from Sprague Dawley (SD) rats with these two imaging systems were demonstrated. Both imaging systems enable the use of one imaging probe for performing two different imaging, thereby improving prognosis by early detection and reducing costs. For integrated PA/US, the architectural morphology and vasculature of the rectum wall were visualized without the usage of contrast agent, but slow imaging speed and usage of match medium are the main limitations for clinical translation. With regard to the integrated OCT/NIR fluorescence, it is able to perform high speed imaging, however the addition of contrast agent and limited imaging depth are the main concern for clinical application.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2520537DOIArticle
Additional Information:© 2019 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported by grants from the National Institutes of Health (R01HL-125084, R01HL-127271, R01EY-026091, R01EY-021529, and P41EB-015890) and the Air Force Office of Scientific Research (FA9550-17-1-0193). Dr. Chen has a financial interest in OCT Medical Imaging, Inc., which, however, did not support this work. Funding: National Institutes of Health (R01HL-125084, R01HL-127271, R01EY-026091, R01EY-021529, and P41EB-015890); Air Force Office of Scientific Research (FA9550-17-1-0193).
Funders:
Funding AgencyGrant Number
NIHR01HL-125084
NIHR01HL-127271
NIHR01EY-026091
NIHR01EY-021529
NIHP41EB-015890
Air Force Office of Scientific Research (AFOSR)FA9550-17-1-0193
Subject Keywords:optical coherence tomography, infrared fluorescence, photoacoustic, ultrasound, multimodality, layered architecture, subsurface Microvasculature, gastrointestinal tract
Series Name:Proceedings of SPIE
Issue or Number:11052
Record Number:CaltechAUTHORS:20190506-135609015
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190506-135609015
Official Citation:Yan Li and Zhongping Chen "Multimodality endoscopic imaging technology for visualization of layered architecture and vasculature", Proc. SPIE 11052, Third International Conference on Photonics and Optical Engineering, 110520B (24 January 2019); doi: 10.1117/12.2520537; https://doi.org/10.1117/12.2520537
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95255
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 May 2019 21:11
Last Modified:03 Oct 2019 21:11

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