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Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing

Liu, Jian and Williams, Brian A. and Gwirtz, Richele M. and Wold, Barbara J. and Quake, Stephen (2006) Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing. Angewandte Chemie International Edition, 45 (22). pp. 3618-3623. ISSN 1433-7851. https://resolver.caltech.edu/CaltechAUTHORS:20190507-151408505

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Abstract

Order from chaos: Microfluidic chaotic mixing shows a significant improvement in the equilibration time of hybridization in DNA microarrays over conventional techniques. These results illustrate a new concept for performing kinetics studies in microfluidic devices.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/anie.200503830DOIArticle
ORCID:
AuthorORCID
Liu, Jian0000-0001-8552-1400
Wold, Barbara J.0000-0003-3235-8130
Additional Information:© 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: October 29, 2005; Revised: February 16, 2006; Published online: April 26, 2006. This research was supported by the NIH Director’s Pioneer Award (7DP1 0D000251-02) and NIH 1R01 HG002644-01A1. We thank Yanxia Hao and Dr. Christopher S. Baker of the Genomics Core Laboratory, Gladstone Institutes for providing mouse-printed oligoarrays (17 K) and Frederick Balagadde of Caltech for technical assistance.
Funders:
Funding AgencyGrant Number
NIH7DP1 0D000251-02
NIH1R01 HG002644-01A1
Subject Keywords:analytical methods; DNA microarrays; gene expression; hybridization; mixing devices
Issue or Number:22
Record Number:CaltechAUTHORS:20190507-151408505
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190507-151408505
Official Citation:Liu, J. , Williams, B. A., Gwirtz, R. M., Wold, B. J. and Quake, S. (2006), Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing. Angewandte Chemie International Edition, 45: 3618-3623. doi:10.1002/anie.200503830
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95326
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 May 2019 22:22
Last Modified:09 Mar 2020 13:19

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