Liu, Jian and Williams, Brian A. and Gwirtz, Richele M. and Wold, Barbara J. and Quake, Stephen (2006) Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing. Angewandte Chemie International Edition, 45 (22). pp. 3618-3623. ISSN 1433-7851. doi:10.1002/anie.200503830. https://resolver.caltech.edu/CaltechAUTHORS:20190507-151408505
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Abstract
Order from chaos: Microfluidic chaotic mixing shows a significant improvement in the equilibration time of hybridization in DNA microarrays over conventional techniques. These results illustrate a new concept for performing kinetics studies in microfluidic devices.
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| Additional Information: | © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: October 29, 2005; Revised: February 16, 2006; Published online: April 26, 2006. This research was supported by the NIH Director’s Pioneer Award (7DP1 0D000251-02) and NIH 1R01 HG002644-01A1. We thank Yanxia Hao and Dr. Christopher S. Baker of the Genomics Core Laboratory, Gladstone Institutes for providing mouse-printed oligoarrays (17 K) and Frederick Balagadde of Caltech for technical assistance. | ||||||
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| Subject Keywords: | analytical methods; DNA microarrays; gene expression; hybridization; mixing devices | ||||||
| Issue or Number: | 22 | ||||||
| DOI: | 10.1002/anie.200503830 | ||||||
| Record Number: | CaltechAUTHORS:20190507-151408505 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190507-151408505 | ||||||
| Official Citation: | Liu, J. , Williams, B. A., Gwirtz, R. M., Wold, B. J. and Quake, S. (2006), Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing. Angewandte Chemie International Edition, 45: 3618-3623. doi:10.1002/anie.200503830 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 95326 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 07 May 2019 22:22 | ||||||
| Last Modified: | 16 Nov 2021 17:11 |
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