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Arginine methylation as a molecular signature of the Piwi small RNA pathway

Vagin, Vasily V. and Hannon, Gregory J. and Aravin, Alexei A. (2009) Arginine methylation as a molecular signature of the Piwi small RNA pathway. Cell Cycle, 8 (24). pp. 4003-4004. ISSN 1538-4101. PMCID PMC2993161.

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Almost all eukaryotes have small RNA pathways that regulate expression of protein-coding genes, control the activity of endogenous transposable elements and fight exogenous viral infection. Despite diversity of small RNA pathways functions and mechanisms, their core is conserved throughout evolution: it is an effector complex containing a small RNA that is tightly bound to a member of the Argonaute protein family. The small RNA provides specificity by recognition of complementary RNA targets. The Argonaute protein provides the effector function; it either destroys target RNA directly using its endonuclease activity or inhibits it indirectly, for example by recruiting additional protein factors that cause translational repression (in animals) or inducing changes in chromatin structure (in fission yeast and possibly some plants).

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Additional Information:© 2009 Taylor & Francis. Submitted: 07/31/09; Accepted: 09/21/09. Published online: 15 Dec 2009. This work was supported by grants from the National Institutes of Health to G.J.H. and an NIH Pathway to Independence Award K99HD057233 to A.A.A.
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Issue or Number:24
PubMed Central ID:PMC2993161
Record Number:CaltechAUTHORS:20190508-111053464
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Official Citation:Vasily V. Vagin, Gregory J. Hannon & Alexei A. Aravin (2009) Arginine methylation as a molecular signature of the Piwi small RNA pathway, Cell Cycle, 8:24, 4003-4004, DOI: 10.4161/cc.8.24.10146
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95347
Deposited By: Tony Diaz
Deposited On:09 May 2019 17:43
Last Modified:03 Oct 2019 21:12

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