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Analysis of Large-Scale Sequencing of Small RNAs

Olson, A. J. and Brennecke, J. and Aravin, A. A. and Hannon, G. J. and Sachidanandam, R. (2008) Analysis of Large-Scale Sequencing of Small RNAs. In: Pacific Symposium on Biocomputing 2008. World Scientific , Hackensack, NJ, pp. 126-136. ISBN 9789812776082.

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The advent of large-scale sequencing has opened up new areas of research, such as the study of Piwi-interacting small RNAs (piRNAs). piRNAs are longer than miRNAs, close to 30 nucleotides in length, involved in various functions, such as the suppression of transposons in germline 3,4,5. Since a large number of them (many tens of thousands) are generated from a wide range of positions in the genome, large-scale sequencing is the only way to study them. The key to understanding their genesis and biological roles is efficient analysis, which is complicated by the large volumes of sequence data. Taking account of the underlying biology is also important. We describe here novel analyses techniques and tools applied to small RNAs from germ cells in D. melanogaster, that allowed us to infer mechanism and biological function.

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Additional Information:© 2008 World Scientific Publishing Company. The authors acknowledge the help of Ted Roeder and Ankit Patel with various aspects of the front end for the web-based software and the anonymous reviewers for suggesting numerous improvements to the manuscript.
Record Number:CaltechAUTHORS:20190509-081714112
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95361
Deposited By: Tony Diaz
Deposited On:09 May 2019 17:31
Last Modified:16 Nov 2021 17:12

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