Tulin, A. V. and Naumova, N. M. and Aravin, A. A. and Gvozdev, V. A. (1998) Repeated, protein-encoding heterochromatic genes cause inactivation of a juxtaposed euchromatic gene. FEBS Letters, 425 (3). pp. 513-516. ISSN 0014-5793. doi:10.1016/s0014-5793(98)00286-5. https://resolver.caltech.edu/CaltechAUTHORS:20190509-083248818
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Abstract
Euchromatic genes are often silenced by rearrangements that place them within or near heterochromatin, a phenomenon known as position effect variegation (PEV). However, little is known about molecular structure of cis‐acting heterochromatic fragments responsible for PEV. Here we report that heterochromatic cluster containing Stellate repeats, that encode putative regulatory subunit of protein kinase CK2 cause PEV of a reporter white `mini‐gene'. It is the first example of an euchromatic gene being silenced because of the proximity to the natural, well‐defined heterochromatic repeat cluster.
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| Additional Information: | © 1998 Federation of European Biochemical Societies. Received 30 January 1998; revised version received 3 February 1998. First published: 14 April 1998. The authors thanks Dr. N.G. Shostak for her help in Drosophila germline transformation experiments, Dr. E.G. Pasyukova for detection of the sites of insertions by in situ hybridization and Dr. E. Kurenova for her help to document variations in eye color. This research was supported by the grants from Russian Foundation of Basic Researches (96‐04‐49026 and 96‐15‐98072) and Russian Program Frontiers in Genetics. | ||||||||
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| Subject Keywords: | Heterochromatic repeat; Position effect variegation; Mini-gene white | ||||||||
| Issue or Number: | 3 | ||||||||
| DOI: | 10.1016/s0014-5793(98)00286-5 | ||||||||
| Record Number: | CaltechAUTHORS:20190509-083248818 | ||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190509-083248818 | ||||||||
| Official Citation: | Tulin, A.V, Naumova, N.M, Aravin, A.A and Gvozdev, V.A( 1998), Repeated, protein-encoding heterochromatic genes cause inactivation of a juxtaposed euchromatic gene, FEBS Letters, 425, doi: 10.1016/S0014-5793(98)00286-5 | ||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
| ID Code: | 95362 | ||||||||
| Collection: | CaltechAUTHORS | ||||||||
| Deposited By: | Tony Diaz | ||||||||
| Deposited On: | 09 May 2019 17:21 | ||||||||
| Last Modified: | 16 Nov 2021 17:12 |
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