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The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, Alexei A. and Hannon, Gregory J. and Brennecke, Julius (2007) The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race. Science, 318 (5851). pp. 761-764. ISSN 0036-8075.

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Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.

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Additional Information:© 2007 American Association for the Advancement of Science. Received 14 June 2007; accepted 17 August 2007. We thank members of the Hannon lab for stimulating discussions. A.A.A. was supported by a Cold Spring Harbor Laboratory Association Fellowship and J.B. was supported by the Schering Foundation. This work was supported by grants from the NIH (G.J.H.) and by a generous gift from Kathyrn W. Davis.
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Cold Spring Harbor LaboratoryUNSPECIFIED
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Issue or Number:5851
Record Number:CaltechAUTHORS:20190509-083948927
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Official Citation:The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race. BY ALEXEI A. ARAVIN, GREGORY J. HANNON, JULIUS BRENNECKE SCIENCE 02 NOV 2007 : 761-764; doi: 10.1126/science.1146484
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95363
Deposited By: Tony Diaz
Deposited On:09 May 2019 17:19
Last Modified:03 Oct 2019 21:12

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