A Caltech Library Service

GATE retrotransposon in Drosophila melanogaster: mobility in heterochromatin and aspects of its expression in germline tissues

Kogan, G. L. and Tulin, A. V. and Aravin, A. A. and Abramov, Yu. A. and Kalmykova, A. I. and Maisonhaute, C. and Gvozdev, V. A. (2003) GATE retrotransposon in Drosophila melanogaster: mobility in heterochromatin and aspects of its expression in germline tissues. Molecular Genetics and Genomics, 269 (2). pp. 234-242. ISSN 1617-4615. doi:10.1007/s00438-003-0827-1.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


A full-length copy of the retrotransposon GATE was identified as an insertion in the tandemly repeated, heterochromatic, Stellate genes, which are expressed in the testis of Drosophila melanogaster. Sequencing of this heterochromatic GATE copy revealed that it is closely related to the BEL retrotransposon, a representative of the recently defined BEL -like group of LTR retrotransposons. This copy contains identical LTRs, indicating that the insertion is a recent event. By contrast, the euchromatic part of the D. melanogaster genome contains only profoundly damaged GATE copies or fragments of the transposon. The preferential localization of GATE sequences in heterochromatin was confirmed for the other species in themelanogaster subgroup. The level of GATE expression is dramatically increased in ovaries, but not in testes, of spn-E^1 homozygous flies. We speculate that spn-E is involved in the silencing of GATE via an RNA interference mechanism.

Item Type:Article
Related URLs:
URLURL TypeDescription ReadCube access
Additional Information:© 2003 Springer-Verlag. Received: 15 October 2002; Accepted: 27 January 2003; Published online: 14 March 2003. We are grateful to M. B. Evgen'ev and B. D. McKee for the gifts of various species of flies. This work was supported by grants from the Russian Foundation for Basic Research (N 00-15-97896, 01-04-22001, 01-04-48514, 02-04-48498, and PICS N1191).
Funding AgencyGrant Number
Russian Foundation for Basic Research00-15-97896
Russian Foundation for Basic Research01-04-22001
Russian Foundation for Basic Research01-04-48514
Russian Foundation for Basic Research02-04-48498
Russian Foundation for Basic ResearchPICS N1191
Subject Keywords:Drosophila melanogaster; Retrotransposon; Heterochromatin; RNA interference
Issue or Number:2
Record Number:CaltechAUTHORS:20190513-074617352
Persistent URL:
Official Citation:Kogan, G.L., Tulin, A.V., Aravin, A.A. et al. Mol Gen Genomics (2003) 269: 234.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95416
Deposited By: Tony Diaz
Deposited On:13 May 2019 16:35
Last Modified:16 Nov 2021 17:12

Repository Staff Only: item control page