A Caltech Library Service

Morphogenesis of the vulva and the vulval-uterine connection

Gupta, Bhagwati P. and Hanna-Rose, Wendy and Sternberg, Paul W. (2012) Morphogenesis of the vulva and the vulval-uterine connection. WormBook: the online review of C. elegans biology . Art. No. 1.152.1. ISSN 1551-8507. PMCID PMC5402222.

[img] PDF - Published Version
Creative Commons Attribution.


Use this Persistent URL to link to this item:


The C. elegans hermaphrodite vulva is an established model system to study mechanisms of cell fate specification and tissue morphogenesis. The adult vulva is a tubular shaped organ composed of seven concentric toroids that arise from selective fusion between differentiated vulval progeny. The dorsal end of the vulval tubule is connected to the uterus via a multinucleate syncytium utse (uterine-seam) cell. The vulval tubule and utse are formed as a result of changes in morphogenetic processes such as cell polarity, adhesion, and invagination. A number of genes controlling these processes are conserved all the way up to human and function in similar developmental contexts. This makes it possible to extend the findings to other metazoan systems. Gene expression studies in the vulval and uterine cells have revealed the presence of regulatory networks specifying distinct cell fates. Thus, these two cell types serve as a good system to understand how gene networks confer unique cell identities both experimentally and computationally. This chapter focuses on morphogenetic processes during the formation of the vulva and its connection to uterus.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2012 Gupta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Edited by Barbara Meyer. Last revised June 8, 2012. Published November 30, 2012. We thank members of our laboratories for discussion and feedback. BPG is supported by funds from NSERC, CIHR and Ministry of Research and Innovation (through ERA program). WHR is supported by R01 GM086786 from the NIH and IOS-071867 from the NSF. PWS is an investigator of the Howard Hughes Medical Institute.
Funding AgencyGrant Number
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Canadian Institutes of Health Research (CIHR)UNSPECIFIED
Ontario Ministry of Research and InnovationUNSPECIFIED
NIHR01 GM086786
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
PubMed Central ID:PMC5402222
Record Number:CaltechAUTHORS:20190513-132517279
Persistent URL:
Official Citation:Gupta, B. P. et al. Morphogenesis of the vulva and the vulval-uterine connection (November 30, 2012), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.152.1,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95439
Deposited By: Tony Diaz
Deposited On:13 May 2019 21:40
Last Modified:15 Apr 2020 22:30

Repository Staff Only: item control page