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Stellate Repeats: Targets of Silencing and Modules Causing cis-Inactivation and trans-Activation

Gvozdev, Vladimir A. and Aravin, Alexei A. and Abramov, Yury A. and Klenov, Mikhail S. and Kogan, Galina L. and Lavrov, Sergei A. and Naumova, Natalia M. and Olenkina, Oxana M. and Tulin, Alexei V. and Vagin, Vasili V. (2003) Stellate Repeats: Targets of Silencing and Modules Causing cis-Inactivation and trans-Activation. Genetica, 117 (2-3). pp. 239-245. ISSN 0016-6707.

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The mechanism of silencing of testis expressed X-linked Stellate repeats by homologous Y-linked Suppressor of Stellate [Su(Ste)] repeats localized in the crystal locus was studied. The double stranded RNA as a product of symmetrical transcription of Su(Ste) repeat and small iinterfaceSu(Ste) siRNA were revealed suggesting the mechanism of RNA interference (RNAi) for Stellate silencing. The relief of Stellate silencing as a result of impaired complementarity between the sequences of putative target Stellate transcripts and Su(Ste) repeats was shown. The role of RNAi mechanism in the silencing of heterochromatic retrotransposon GATE inserted in Stellate cluster was revealed. The studies of cis-effects of Stellate tandem repeats causing variegated expression of juxtaposed reporter genes were extended and the lacZ variegation in imaginal disc was shown. The exceptional case of a non-variegated expression of mini-white gene juxtaposed to Stellate repeats in a construct inserted into the 39C region was shown to be accompanied by trans-activation in homozygous state. Trans-activation effect was retained after transposition of this construct into heterochromatic environment in spite of strong variegation of a mini-white gene.

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Additional Information:© 2003 Kluwer Academic Publishers. We are thankful to C. Tummel for the P[w+] DHR stock. This work was supported by grants from Russian Foundation for Basic Researches (01-04-48514, 00-15-97896, 01-04-06425, 01-04-06426, 01-04-06427, 01-04-06428) and Programs ‘Frontiers in Genetics’ N 99-1-069.
Funding AgencyGrant Number
Russian Foundation for Basic Research01-04-48514
Russian Foundation for Basic Research00-15-97896
Russian Foundation for Basic Research01-04-06425
Russian Foundation for Basic Research01-04-06426
Russian Foundation for Basic Research01-04-06427
Russian Foundation for Basic Research01-04-06428
Russian Foundation for Basic Research99-1-069
Subject Keywords:heterochromatic repeats, PEV, retrotransposon, RNA interference, Y chromosome
Issue or Number:2-3
Record Number:CaltechAUTHORS:20190513-133559461
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Official Citation:Gvozdev, V.A., Aravin, A.A., Abramov, Y.A. et al. Genetica (2003) 117: 239.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95440
Deposited By: Tony Diaz
Deposited On:13 May 2019 21:34
Last Modified:03 Oct 2019 21:13

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