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Role of Double-Stranded RNA in Eukaryotic Gene Silencing

Aravin, A. A. and Klenov, M. S. and Vagin, V. V. and Rozovskii, Ya. M. and Gvozdev, V. A. (2002) Role of Double-Stranded RNA in Eukaryotic Gene Silencing. Molecular Biology, 36 (2). pp. 180-188. ISSN 0026-8933.

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Data on RNA interference, that is, posttranscriptional gene silencing by homologous double-stranded (ds) RNA, are reviewed. Gene silencing caused by exogenous dsRNA in artificial systems and observed in transgenic organisms carrying additional gene copies is considered. Data are summarized on the mechanism that arose during evolution of the Drosophila melanogaster genome to suppress repetitive genes with the use of dsRNA and thereby to prevent male sterility. The role of dsRNA in inhibiting expression and transposition of mobile elements is discussed on the basis of authors' own and published findings.

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Additional Information:© 2002 MAIK “Nauka/Interperiodica”. Translated from Molekulyarnaya Biologiya, Vol. 36, No. 2, 2002, pp. 240–251. Original Russian Text Copyright © 2002 by Aravin, Klenov, Vagin, Rozovskii, Gvozdev. Received October 10, 2001. This work was supported by the Russian Foundation for Basic Research (project nos. 99-04-48561, 01-04-48514, 00-15-97896, 01-04-06427, 01-04-06428) and the Russian program Frontiers in Genetics (project no. 99-1-069).
Funding AgencyGrant Number
Russian Foundation for Basic Research99-04-48561
Russian Foundation for Basic Research01-04-48514
Russian Foundation for Basic Research00-15-97896
Russian Foundation for Basic Research01-04-06427
Russian Foundation for Basic Research01-04-06428
Russian Foundation for Basic Research99-1-069
Subject Keywords:gene expression; RNA interference; posttranscriptional regulation; suppression Drosophila
Issue or Number:2
Record Number:CaltechAUTHORS:20190513-134220628
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Official Citation:Aravin, A.A., Klenov, M.S., Vagin, V.V. et al. Molecular Biology (2002) 36: 180.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95441
Deposited By: Tony Diaz
Deposited On:13 May 2019 21:23
Last Modified:03 Oct 2019 21:13

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