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WormBase - Annotating many nematode genomes

Howe, Kevin and Davis, Paul and Paulini, Michael and Tuli, Mary Ann and Williams, Gary and Yook, Karen and Durbin, Richard and Kersey, Paul and Sternberg, Paul W. (2012) WormBase - Annotating many nematode genomes. Worm, 1 (1). pp. 15-21. ISSN 2162-4054. PMCID PMC3670165. https://resolver.caltech.edu/CaltechAUTHORS:20190514-075525922

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Abstract

WormBase (www.wormbase.org) has been serving the scientific community for over 11 years as the central repository for genomic and genetic information for the soil nematode Caenorhabditis elegans. The resource has evolved from its beginnings as a database housing the genomic sequence and genetic and physical maps of a single species, and now represents the breadth and diversity of nematode research, currently serving genome sequence and annotation for around 20 nematodes. In this article, we focus on WormBase’s role of genome sequence annotation, describing how we annotate and integrate data from a growing collection of nematode species and strains. We also review our approaches to sequence curation, and discuss the impact on annotation quality of large functional genomics projects such as modENCODE.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.4161/worm.19574DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670165PubMed CentralArticle
ORCID:
AuthorORCID
Yook, Karen0000-0002-4457-6787
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2012 Landes Bioscience. Submitted: 11/02/11; Revised: 02/02/12; Accepted: 02/02/12. This work is supported by the US National Institutes of Health (Grant no. P41 HG02223); US National Human Genome Research Institute (Grant no. P41-HG02223); and British Medical Research Council (Grant no. G070119); P.W.S. is an investigator with the Howard Hughes Medical Institute. Funding for open access charge: US National Human Genome Research Institute (Grant no. P41-HG02223).
Funders:
Funding AgencyGrant Number
NIHP41 HG02223
Medical Research Council (UK)G070119
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:Caenorhabditis elegans , annotation, community resource, genome, model organism database, nematode, parasitic nematode, sequence curation
Issue or Number:1
PubMed Central ID:PMC3670165
Record Number:CaltechAUTHORS:20190514-075525922
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190514-075525922
Official Citation:Kevin Howe, Paul Davis, Michael Paulini, Mary Ann Tuli, Gary Williams, Karen Yook, Richard Durbin, Paul Kersey & Paul W. Sternberg (2012) WormBase, Worm, 1:1, 15-21, DOI: 10.4161/worm.19574
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95463
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 May 2019 21:22
Last Modified:29 Oct 2019 20:10

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