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NanoSystems biology

Heath, James R. and Phelps, Michael E. and Hood, Leroy (2003) NanoSystems biology. Molecular Imaging and Biology, 5 (5). pp. 312-325. ISSN 1536-1632. doi:10.1016/j.mibio.2003.10.001.

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Systems biology is an approach in which the digital information of the genome, acted upon by environmental cues, generates the many molecular signatures of gene and protein expression, as well as other, more phenomenological experimental observations. These data may be integrated together to form a testable hypothesis of how a biological organism functions as a system. The central components of systems biology are genetically programmed networks (circuits) within cells and networks of cells. These components establish the organization and function of individual cells and tissues in response to environmental signals such as cell-to-cell communication within organ systems and whole organisms. Within this context, disease is considered as a genetic or environmental reprogramming of cells to gain or lose specific functions that are characteristics of disease. This paper is a combination of three tutorials with an outlined series of technologies, including microfluidics, nanotechnologies, and molecular imaging methods, and we describe how their development should be driven by the needs of systems biology. We also discuss how these technologies can enable a systems biology approach through a pathway from single cells to mouse models of disease and finally to patients. Within this technology base are approaches to develop, use and test molecules as probes that target proteins, DNA and mRNA to test systems biology models, as well as provide molecular diagnostics and molecular therapeutics within a systems biology framework.

Item Type:Article
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URLURL TypeDescription
Heath, James R.0000-0001-5356-4385
Hood, Leroy0000-0001-7158-3678
Additional Information:© 2003 Elsevier Inc. Available online 15 November 2003.
Subject Keywords:Nanotechnology; Microfluidics; Systems biology; Positron emission tomography (PET); Molecular imaging; Integrated microfluidics; Molecular probes
Issue or Number:5
Record Number:CaltechAUTHORS:20190516-085234738
Persistent URL:
Official Citation:James R Heath, Michael E Phelps, Leroy Hood, NanoSystems biology, Molecular Imaging & Biology, Volume 5, Issue 5, 2003, Pages 312-325, ISSN 1536-1632, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95531
Deposited By: Tony Diaz
Deposited On:16 May 2019 17:43
Last Modified:16 Nov 2021 17:13

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