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Active Learning of Spin Network Models

Jiang, Jialong and Sivak, David A. and Thomson, Matt (2019) Active Learning of Spin Network Models. . (Unpublished)

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The inverse statistical problem of finding direct interactions in complex networks is difficult. In the context of the experimental sciences, well-controlled perturbations can be applied to a system, probing the internal structure of the network. Therefore, we propose a general mathematical framework to study inference with iteratively applied perturbations to a network. Formulating active learning in the language of information geometry, our framework quantifies the difficulty of inference as well as the information gain due to perturbations through the curvature of the underlying parameter manifold as measured though the empirical Fisher information. Perturbations are then chosen that reduce most the variance of the Bayesian posterior. We apply this framework to a specific probabilistic graphical model where the nodes in the network are modeled as binary variables, "spins" with Ising-form pairwise interactions. Based on this strategy, we significantly improve the accuracy and efficiency of inference from a reasonable number of experimental queries for medium sized networks. Our active learning framework could be powerful in the analysis of complex networks as well as in the rational design of experiments.

Item Type:Report or Paper (Discussion Paper)
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Additional Information:This manuscript was compiled on May 15, 2019. The authors would like to thank Venkat Chandrasekaran and Andrew Stuart for influential discussions, and Yifan Chen for helpful suggestions. The authors would like to acknowledge support from the the Heritage Medical Research Institute (MT), the NIH (DP5 OD012194) (MT), and the Natural Sciences and Engineering Research Council (NSERC) Discovery Grant (DAS), and a Tier-II Canada Research Chair (DAS).
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
NIHDP5 OD012194
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Canada Research Chairs ProgramUNSPECIFIED
Subject Keywords:Network; Inference; Active Learning; Information Geometry
Record Number:CaltechAUTHORS:20190520-085022351
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95586
Deposited By: Tony Diaz
Deposited On:20 May 2019 15:56
Last Modified:03 Oct 2019 21:14

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