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Extending the wavelength range of multi-spectral microscope systems with Fourier ptychography

Chan, Antony Chi Shing and Shen, Cheng and Williams, Elliot and Lyu, Xiaoyu and Lu, Hangwen and Ives, Craig and Hajimiri, Ali and Yang, Changhuei (2019) Extending the wavelength range of multi-spectral microscope systems with Fourier ptychography. In: Label-free Biomedical Imaging and Sensing (LBIS) 2019. Proceedings of SPIE. No.10890. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 108902O. ISBN 9781510624221.

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Due to the chromatic dispersion properties inherent in all optical materials, even the best designed multi-spectral objective will exhibit residual chromatic aberration effect. Here we show that the aberration correction ability of Fourier Ptychographic Microscopy (FPM) is well matched and well suited for post-image acquisition correction of these effects to render in-focus images. We show that an objective with significant spectral focal shift (up to 0.02 μm/nm) and spectral field curvature (up to 0.05 μm/nm drift at off-axis position of 800μm) can be computationally corrected to render images with effectively null spectral defocus and field curvature. This approach of combining optical objective design and computational microscopy provides a good strategy for high quality multi-spectral imaging over a broad spectral range, and eliminating the need for mechanical actuation solutions.

Item Type:Book Section
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URLURL TypeDescription
Shen, Cheng0000-0001-7136-4715
Hajimiri, Ali0000-0001-6736-8019
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2019 Society of Photo-Optical Instrumentation Engineers (SPIE).
Series Name:Proceedings of SPIE
Issue or Number:10890
Record Number:CaltechAUTHORS:20190522-154638477
Persistent URL:
Official Citation:Antony Chi Shing Chan, Cheng Shen, Elliott Williams, Xiaoyu Lyu, Hangwen Lu, Craig Ives, Ali Hajimiri, and Changhuei Yang "Extending the wavelength range of multi-spectral microscope systems with Fourier ptychography", Proc. SPIE 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, 108902O (25 March 2019); doi: 10.1117/12.2510875;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95718
Deposited By: George Porter
Deposited On:23 May 2019 14:34
Last Modified:16 Nov 2021 17:14

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