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Human heterozygosity: A new estimate

McConkey, Edwin H. and Taylor, Beverley J. and Phan, Duc (1979) Human heterozygosity: A new estimate. Proceedings of the National Academy of Sciences of the United States of America, 76 (12). pp. 6500-6504. ISSN 0027-8424.

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Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.

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Additional Information:© 1979 by the National Academy of Sciences. Communicated by Frank H. Ruddle, September 4, 1979. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:fibroblast polypeptides; two-dimensional gel electrophoresis; double-label autoradiography
Issue or Number:12
Record Number:CaltechAUTHORS:MCCpnas79
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9581
Deposited By: Tony Diaz
Deposited On:11 Feb 2008
Last Modified:03 Oct 2019 00:01

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