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Bacterial Controller Aided Wound Healing: A Case Study in Dynamical Population Controller Design

Green, Leopold N. and Hu, Chelsea Y. and Ren, Xinying Y. and Murray, Richard M. (2019) Bacterial Controller Aided Wound Healing: A Case Study in Dynamical Population Controller Design. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20190604-143031841

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Abstract

Wound healing is a complicated biological process consisting of many types of cellular dy- namics and functions regulated by chemical and molecular signals. Recent advances in synthetic biology have made it possible to predictably design and build closed-loop controllers that can function appropriately alongside biological species. In this paper we develop a simple dynamical population model mimicking the sequential relay-like dynamics of cellular populations involved in the wound healing process. Our model consists of four nodes and five signals whose pa- rameters we can tune to simulate various chronic healing conditions. We also develop a set of regulator functions based on type-1 incoherent feed forward loops (IFFL) that can sense the change from acute healing to incomplete chronic wounds, improving the system in a timely manner. Both the wound healing and type-1 IFFL controller architectures are compatible with available synthetic biology experimental tools for potential applications.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/659714DOIDiscussion Paper
ORCID:
AuthorORCID
Hu, Chelsea Y.0000-0002-2211-1778
Murray, Richard M.0000-0002-5785-7481
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. bioRxiv preprint first posted online Jun. 4, 2019. The authors would like to thank Reed McCardell, William Poole, Ayush Pandey and Mark Prator for their insightful discussion. The authors L. G., X. R., and C. H. are supported by Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)HR0011-17-2-0008
Record Number:CaltechAUTHORS:20190604-143031841
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190604-143031841
Official Citation:Bacterial Controller Aided Wound Healing: A Case Study in Dynamical Population Controller Design. Leopold N. Green Jr., Chelsea Y. Hu, Xinying Y. Ren, Richard M Murray. bioRxiv 659714; doi: https://doi.org/10.1101/659714.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96116
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Jun 2019 21:55
Last Modified:03 Oct 2019 21:19

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