Rothenberg, Ellen V. (2001) Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis. Proceedings of the National Academy of Sciences of the United States of America, 98 (12). pp. 6540-6542. ISSN 0027-8424. PMCID PMC34387. https://resolver.caltech.edu/CaltechAUTHORS:ROTpnas01
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Abstract
Vertebrate hematopoiesis is a richly complex developmental system in which many transcription factors have essential and nonredundant roles (1). Some factors act as prominent controllers of differentiation in specific cell lineages, others are needed for stem cell generation, and others are needed for both. In this system, precise levels of one transcription factor relative to another in the same cell can control the direction of cell lineage choices, proliferation vs. apoptosis, lineage-specific malignant transformation, and the timing and sites of stem cell generation (2–9).
| Item Type: | Article | ||||||
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| Additional Information: | © 2001 by the National Academy of Sciences. | ||||||
| Issue or Number: | 12 | ||||||
| PubMed Central ID: | PMC34387 | ||||||
| Record Number: | CaltechAUTHORS:ROTpnas01 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:ROTpnas01 | ||||||
| Alternative URL: | http://www.pnas.org/cgi/content/extract/98/12/6540 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 962 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 15 Nov 2005 | ||||||
| Last Modified: | 02 Oct 2019 22:38 |
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