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Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis

Rothenberg, Ellen V. (2001) Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis. Proceedings of the National Academy of Sciences of the United States of America, 98 (12). pp. 6540-6542. ISSN 0027-8424. PMCID PMC34387. https://resolver.caltech.edu/CaltechAUTHORS:ROTpnas01

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Abstract

Vertebrate hematopoiesis is a richly complex developmental system in which many transcription factors have essential and nonredundant roles (1). Some factors act as prominent controllers of differentiation in specific cell lineages, others are needed for stem cell generation, and others are needed for both. In this system, precise levels of one transcription factor relative to another in the same cell can control the direction of cell lineage choices, proliferation vs. apoptosis, lineage-specific malignant transformation, and the timing and sites of stem cell generation (2–9).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34387/PubMed CentralArticle
ORCID:
AuthorORCID
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2001 by the National Academy of Sciences.
Issue or Number:12
PubMed Central ID:PMC34387
Record Number:CaltechAUTHORS:ROTpnas01
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:ROTpnas01
Alternative URL:http://www.pnas.org/cgi/content/extract/98/12/6540
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:962
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Nov 2005
Last Modified:02 Oct 2019 22:38

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