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On the relationship between synaptic input and spike output jitter in individual neurons

Marsálek, Petr and Koch, Christof and Maunsell, John (1997) On the relationship between synaptic input and spike output jitter in individual neurons. Proceedings of the National Academy of Sciences of the United States of America, 94 (2). pp. 735-740. ISSN 0027-8424. PMCID PMC19583.

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What is the relationship between the temporal jitter in the arrival times of individual synaptic inputs to a neuron and the resultant jitter in its output spike? We report that the rise time of firing rates of cells in striate and extrastriate visual cortex in the macaque monkey remain equally sharp at different stages of processing. Furthermore, as observed by others, multiunit recordings from single units in the primate frontal lobe reveal a strong peak in their cross-correlation in the 10-150 msec range with very small temporal jitter (on the order of 1 msec). We explain these results using numerical models to study the relationship between the temporal jitter in excitatory and inhibitory synaptic input and the variability in the spike output timing in integrate-and-fire units and in a biophysically and anatomically detailed model of a cortical pyramidal cell. We conclude that under physiological circumstances, the standard deviation in the output jitter is linearly related to the standard deviation in the input jitter, with a constant of less than one. Thus, the timing jitter in successive layers of such neurons will converge to a small value dictated by the jitter in axonal propagation times.

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Koch, Christof0000-0001-6482-8067
Additional Information:Copyright © 1997 by the National Academy of Sciences. Communicated by David Mumford, Brown University, Providence, RI, November 18, 1996 (received for review May 21, 1996). We thank G. Holt for his invaluable advice at all stages of this project, in particular in his formulation of Eqs. 1–3 and his help with NEURON. We thank Carrie J. McAdams for providing some of the neurophysiological data in Fig. 1 and for assisting in their analysis. We also thank J. Sykora and M. Stemmler for helpful comments. This research was supported by the National Institute of Mental Health through the Center for Cell and Molecular Signaling, by a National Institute of Mental Health grant to C.K., and by National Institutes of Health Grant EY05911 to J.M. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Group:Koch Laboratory (KLAB)
Subject Keywords:neocortex, firing variability, temporal jitter, integrate-and-fire units, neural networks, visual-cortex, model, cells
Issue or Number:2
PubMed Central ID:PMC19583
Record Number:CaltechAUTHORS:MARpnas97
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Official Citation:Petr Maršálek, Christof Koch, and John Maunsell On the relationship between synaptic input and spike output jitter in individual neurons PNAS 1997 94 (2) 735-740
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:965
Deposited By: Tony Diaz
Deposited On:17 Nov 2005
Last Modified:02 Oct 2019 22:38

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