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Plasticity of functional connectivity in the adult spinal cord

Cai, L. L. and Courtine, G. and Fong, A. J. and Burdick, J. W. and Roy, R. R. and Edgerton, V. R. (2006) Plasticity of functional connectivity in the adult spinal cord. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 361 (1473). pp. 1635-1646. ISSN 0962-8436. PMCID PMC1664672.

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This paper emphasizes several characteristics of the neural control of locomotion that provide opportunities for developing strategies to maximize the recovery of postural and locomotor functions after a spinal cord injury (SCI). The major points of this paper are: (i) the circuitry that controls standing and stepping is extremely malleable and reflects a continuously varying combination of neurons that are activated when executing stereotypical movements; (ii) the connectivity between neurons is more accurately perceived as a functional rather than as an anatomical phenomenon; (iii) the functional connectivity that controls standing and stepping reflects the physiological state of a given assembly of synapses, where the probability of these synaptic events is not deterministic; (iv) rather, this probability can be modulated by other factors such as pharmacological agents, epidural stimulation and/or motor training; (v) the variability observed in the kinematics of consecutive steps reflects a fundamental feature of the neural control system and (vi) machine-learning theories elucidate the need to accommodate variability in developing strategies designed to enhance motor performance by motor training using robotic devices after an SCI.

Item Type:Article
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Additional Information:© 2006 The Royal Society. Theme Issue ‘The regenerating brain: a recapitulation of development?’ compiled by Geoff Cook, James Fawcett, Roger Keynes and Marc Tessier-Lavigne. This work was supported, in part, by NIH grant NS16333.
Funding AgencyGrant Number
Subject Keywords:spinal cord injury; rehabilitation; robotics; locomotion; standing; neural control systems
Issue or Number:1473
PubMed Central ID:PMC1664672
Record Number:CaltechAUTHORS:20190620-093003693
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Official Citation:Cai, L L et al. “Plasticity of functional connectivity in the adult spinal cord.” Philosophical transactions of the Royal Society of London. Series B, Biological sciences vol. 361,1473 (2006): 1635-46. doi:10.1098/rstb.2006.1884
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96585
Deposited By: George Porter
Deposited On:20 Jun 2019 21:03
Last Modified:03 Oct 2019 21:23

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