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Single-neuron correlates of subjective vision in the human medial temporal lobe

Kreiman, Gabriel and Fried, Itzhak and Koch, Christof (2002) Single-neuron correlates of subjective vision in the human medial temporal lobe. Proceedings of the National Academy of Sciences of the United States of America, 99 (12). pp. 8378-8383. ISSN 0027-8424. PMCID PMC123075. http://resolver.caltech.edu/CaltechAUTHORS:KREpnas02

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Abstract

Visual information from the environment is transformed into perceptual sensations through several stages of neuronal processing. Flash suppression constitutes a striking example in which the same retinal input can give rise to two different conscious visual percepts. We directly recorded the responses of individual neurons during flash suppression in the human amygdala, entorhinal cortex, hippocampus, and parahippocampal gyrus, allowing us to explore the neuronal responses in untrained subjects at a high spatial and temporal resolution in the medial temporal lobe. Subjects were patients with pharmacologically intractable epilepsy implanted with depth electrodes to localize the seizure onset focus. We observed that the activity of two thirds of all visually selective neurons followed the perceptual alternations rather than the retinal input. None of the selective neurons responded to a perceptually suppressed stimulus. Therefore, the activity of most individual neurons in the medial temporal lobe of naive human subjects directly correlates with the phenomenal visual experience.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.072194099DOIArticle
http://www.pnas.org/content/99/12/8378.abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC123075/PubMed CentralArticle
ORCID:
AuthorORCID
Fried, Itzhak0000-0002-5962-2678
Koch, Christof0000-0001-6482-8067
Additional Information:Copyright © 2002 by the National Academy of Sciences. Communicated by Francis Crick, The Salk Institute for Biological Studies, San Diego, CA, April 2, 2002 (received for review March 15, 2002). We thank Geraint Rees, Nikos Logothetis, and John Allman for advice throughout this work, all patients for their participation, and Eve Isham, Charles Wilson, Tony Fields, and Eric Behnke for help with the recordings. This work was supported by grants from the National Institutes of Health (National Institute of Mental Health and National Institute of Neurological Disorders and Stroke), National Science Foundation, Mettler Fund for Research Relating to Autism, McDonnell–Pew Program in Cognitive Neuroscience, and the W. M. Keck Foundation Fund for Discovery in Basic Medical Research.
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
National Institute of Mental Health (NIMH)UNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
NSFUNSPECIFIED
Mettler Fund for Research Relating to AutismUNSPECIFIED
McDonnell–Pew Program in Cognitive NeuroscienceUNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
Subject Keywords:binocular-rivalry, human brain, perception, cortex, hippocampus, recognition, responses, memory
PubMed Central ID:PMC123075
Record Number:CaltechAUTHORS:KREpnas02
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KREpnas02
Alternative URL:http://dx.doi.org/10.1073/pnas.072194099
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:966
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Nov 2005
Last Modified:30 Oct 2017 21:13

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