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Improved chemotherapeutic delivery to brain metastases with targeted nanoparticles in preclinical breast cancer brain metastasis models

Wyatt, Emily A. and Davis, Mark E. (2018) Improved chemotherapeutic delivery to brain metastases with targeted nanoparticles in preclinical breast cancer brain metastasis models. Cancer Research, 78 (13). Art. No. 4641. ISSN 0008-5472. doi:10.1158/1538-7445.AM2018-4641. https://resolver.caltech.edu/CaltechAUTHORS:20190620-143428810

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Abstract

Brain metastases present an increasing challenge to long-term survival for HER2-amplified breast cancer patients. While HER2 targeted therapies effectively control systemic metastases, they are largely ineffective against brain metastases due to their inability to cross the blood-brain barrier. We have recently demonstrated that brain uptake of targeted nanoparticles can be increased by adding an acid-cleavable linkage between transferrin (Tf) and the nanoparticle core [1]. Our lab has also developed a method for assembling targeted nanoparticles by complexing diol-containing polymerdrug conjugates and boronic acid-containing targeting agents [2]. Here, we report the first efficacy results of targeted nanoparticles formed via this assembly strategy in a preclinical model of breast cancer brain metastasis.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1158/1538-7445.AM2018-4641DOIArticle
ORCID:
AuthorORCID
Wyatt, Emily A.0000-0002-7534-0582
Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2018 American Association for Cancer Research.
Issue or Number:13
DOI:10.1158/1538-7445.AM2018-4641
Record Number:CaltechAUTHORS:20190620-143428810
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190620-143428810
Official Citation:Abstract 4641: Improved chemotherapeutic delivery to brain metastases with targeted nanoparticles in preclinical breast cancer brain metastasis models. Emily A. Wyatt and Mark E. Davis. Cancer Res July 1 2018 (78) (13 Supplement) 4641; DOI: 10.1158/1538-7445.AM2018-4641
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96603
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Jun 2019 22:15
Last Modified:16 Nov 2021 17:22

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