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Innovative strategies for improved outcomes in nephrolithiasis

Bailey, Michael and Simon, Julianna C. and Kreider, Wayne and Dunmire, Barbrina and Crum, Lawrence and Maxwell, Adam D. and Khokhlova, Vera and Sapozhnikov, Oleg A. and Cleveland, Robin and Colonius, Tim and Lingeman, James E. and McAteer, James and Williams, James C. and Freund, Jonathan (2017) Innovative strategies for improved outcomes in nephrolithiasis. In: 3rd Joint Meeting of the Acoustical Society of America and the European Acoustics Association, 25-29 June 2017, Boston, MA. https://resolver.caltech.edu/CaltechAUTHORS:20190708-164305356

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Abstract

Edwin Carstensen, Ph.D., was an advisor of NIH NIDDK Program Project Grant DK043881, created to investigate shock wave lithotripsy (SWL). We now develop solutions to improve all aspects of the management of stone disease. Our goal in this paper is to report progress built on Dr. Cartsensen's advice and inspiration. The work ranges from numerical simulation to clinical trials and from device development to bioeffects and metrology. Much of our work involves bubbles and cavitation. This work has contributed to the body of knowledge defining limits for the safe use of ultrasound which Dr. Carstensen worked hard to establish. Specifically, an update will be given on the development of ultrasound to image, fragment, trap, and reposition stones. In particular, we demonstrated bubbles contribute to the twinkling artifact used by NASA and others to image stones, and we drew on Dr. Carstensen's paper [UMB, 19(2) 147-165 1993] to demonstrate that breathing the elevated carbon dioxide levels present in NASA vehicles suppresses this signal making stone imaging more difficult. We have since developed imaging countermeasures and pushing and breaking technologies that appear less dependent on cavitation than SWL.


Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1121/1.4988643DOIArticle
https://asa.scitation.org/doi/abs/10.1121/1.4988643PublisherArticle
https://acousticalsociety.org/program-acoustics-17-boston/Related ItemConference Site
https://acousticalsociety.org/wp-content/uploads/2018/02/Boston_Full_Week.pdfRelated ItemConference Program
ORCID:
AuthorORCID
Colonius, Tim0000-0003-0326-3909
Additional Information:© 2017 Acoustical Society of America. Published Online: 10 June 2017. Work supported by NIH P01DK043881, K01DK104854, R01EB007643, and NSBRI through NASA NCC 9-58.
Funders:
Funding AgencyGrant Number
NIHP01DK043881
NIHK01DK104854
NIHR01EB007643
NASANCC 9-58
Subject Keywords:Metrology; Chemical compounds and components; Ultrasound; Computer simulation; Medical diagnosis
Issue or Number:5
Record Number:CaltechAUTHORS:20190708-164305356
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190708-164305356
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96935
Collection:CaltechAUTHORS
Deposited By: Melissa Ray
Deposited On:10 Jul 2019 18:42
Last Modified:03 Oct 2019 21:26

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