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Quantification of the shielding of kidney stones by bubble clouds during burst wave lithotripsy

Maeda, Kazuki and Colonius, Tim and Kreider, Wayne and Maxwell, Adam D. and Bailey, Michael (2017) Quantification of the shielding of kidney stones by bubble clouds during burst wave lithotripsy. In: 3rd Joint Meeting of the Acoustical Society of America and the European Acoustics Association, 25-29 June 2017, Boston, MA.

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Bubble clouds can shield kidney stones from insonification, and limit stone breakage during burst-wave lithotripsy (BWL), a recently proposed technique that uses focused ultrasound pulses with an amplitude of O(1-10) MPa and frequency of O(0.1) MHz. We use numerical simulations to quantify the magnitude of such shielding. In the simulations, we solve for the radial evolution of Lagrangian bubbles coupled to a compressible fluid using volume-averaging techniques. The resulting equations are discretized on an Eulerian grid. In particular, we quantify the reduction in acoustic energy flux incident on a rigid, plane wall that models the stone surface. We consider a burst wave with an amplitude of 6 MPa and a bubble cloud of diameter O(1) mm. The size distribution of nuclei, the number density of bubbles, and the distance of the cloud from the wall are varied, We show that a cloud containing O(10) bubbles with a diameter of O(10) um can reduce the total energy flux by more than 50%, largely independent of distribution of nuclei. Finally, we compare the simulation results with high-speed images and hydrophone measurements of bubble clouds from companion experiments.

Item Type:Conference or Workshop Item (Paper)
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URLURL TypeDescription ItemConference Site ItemConference Program
Maeda, Kazuki0000-0002-5729-6194
Colonius, Tim0000-0003-0326-3909
Additional Information:© 2017 Acoustical Society of America. Published Online: 09 June 2017. Work supported by NIH 2P01-DK043881.
Funding AgencyGrant Number
Subject Keywords:Acoustical properties; Acoustic signal processing; Energy flux; Organs; Hydrophone; Ultrasound; Medical diagnosis
Issue or Number:5
Record Number:CaltechAUTHORS:20190709-092058839
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96949
Deposited By: Melissa Ray
Deposited On:09 Jul 2019 23:45
Last Modified:16 Nov 2021 17:24

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