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Experimental observations and numerical modeling of lipid-shell microbubbles with stone targeting moieties for minimally-invasive treatment of urinary stones

Pishchalnikov, Yuri A. and Behnke-Parks, William and Maeda, Kazuki and Colonius, Tim and Mellema, Matt and Hopcroft, Matt and Luong, Alice and Wiener, Scott and Stoller, Marshall and Kenny, Thomas and Laser, Daniel (2018) Experimental observations and numerical modeling of lipid-shell microbubbles with stone targeting moieties for minimally-invasive treatment of urinary stones. Journal of the Acoustical Society of America, 144 (3). p. 1781. ISSN 0001-4966. https://resolver.caltech.edu/CaltechAUTHORS:20190709-092102441

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Abstract

Products incorporating stone-targeting microbubbles have recently entered human clinical trials as a new minimally-invasive approach to treat urinary stones. Lipid-shell, gas-core microbubbles can be introduced into the urinary tract through a catheter. Calcium-binding moieties incorporated into the lipid shell can facilitate binding to stones. The microbubbles can be excited by an extracorporeal source of low-intensity ultrasound. Alternatively, the microbubbles can be excited by an intraluminal source, such as a fiber-optic laser. With either excitation technique, stone-targeting microbubbles can significantly increase rates of erosion, pitting, and fragmentation of stones, as has recently been reported for in-vitro experiments with synthetic stones [Wiener et al., J. Urology, v.199, no.4S, e322 (2018)]. We report here on new experiments using high-speed photography to characterize microbubbles expansion of cracks within a stone and resultant breaking-off of stone fragments. Numerical modeling shows that the direction of microjets produced by collapsing stone-bound microbubbles depends strongly on bubble shape and stand-off distance. For a wide range of stand-off distances and bubble shapes, microbubble collapse is associated with pressure increases of some two orders of magnitude compared to the excitation source pressures. This in-vitro study provides key insights into the use of stone-targeting microbubbles in treatment of urinary stones.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1121/1.5067871DOIArticle
https://asa.scitation.org/doi/10.1121/1.5067871PublisherArticle
http://resolver.caltech.edu/CaltechAUTHORS:20190123-101938742Related ItemConference Paper
ORCID:
AuthorORCID
Maeda, Kazuki0000-0002-5729-6194
Colonius, Tim0000-0003-0326-3909
Additional Information:© Acoustical Society of America. Published Online: 18 October 2018.
Subject Keywords:Fiber optics; Optical imaging; Chemical elements; Ultrasound; Urology; Lipids; Biomedical equipment; Numerical methods
Issue or Number:3
Record Number:CaltechAUTHORS:20190709-092102441
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190709-092102441
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96980
Collection:CaltechAUTHORS
Deposited By: Melissa Ray
Deposited On:12 Jul 2019 17:14
Last Modified:03 Oct 2019 21:27

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