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Modeling and experimental analysis of acoustic cavitation bubble clouds for burst-wave lithotripsy

Maeda, Kazuki and Colonius, Tim and Kreider, Wayne and Maxwell, Adam and Bailey, Michael (2016) Modeling and experimental analysis of acoustic cavitation bubble clouds for burst-wave lithotripsy. In: 5th Joint Meeting Acoustical Society of America and Acoustical Society of Japan, 28 November-2 December 2016, Honolulu, HI.

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Understanding the dynamics of cavitation bubble clouds formed inside a human body is critical for the design of burst-wave lithotripsy (BWL), a newly proposed method that uses focused ultrasound pulses with amplitude of O(10) MPa and frequency of O(0.1) MHz to fragment kidney stones. We present modeling and three-dimensional direct numerical simulations of interactions between bubble clouds and ultrasound pulses in water. We study two configurations: isolated clouds in a free field, and clouds near a rigid surface. In the modeling, we solve for the bubble radius evolution and continuous flow field using a WENO-based compressible flow solver. In the solver, Lagrangian bubbles are coupled with the continuous phase, defined on an Eulerian grid, at the sub-grid scale using volume averaging techniques. Correlations between the initial void fraction and the maximum collapse pressure in the cloud are discussed. We demonstrate acoustic imaging of the bubbles by post-processing simulated pressure signals at particular sensor locations indicating waves scattered by the clouds. Finally, we compare the simulation results with experimental results including high-speed imaging and hydrophone measurements. The time evolution of the cloud void fraction and the scattered acoustic field in the simulation agree with the experimental results.

Item Type:Conference or Workshop Item (Paper)
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URLURL TypeDescription ItemConference Site ItemConference Program
Maeda, Kazuki0000-0002-5729-6194
Colonius, Tim0000-0003-0326-3909
Additional Information:© Acoustical Society of America. Published Online: 18 November 2016. Funding supported by NIH 2P01-DK043881.
Funding AgencyGrant Number
Subject Keywords:Acoustic signal processing; Fluid flows; Cavitation bubbles; Acoustic field; Acoustical effects; Optical imaging; Organs; Hydrophone; Ultrasound; Medical diagnosis
Record Number:CaltechAUTHORS:20190709-092102986
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:96987
Deposited By: Melissa Ray
Deposited On:12 Jul 2019 20:22
Last Modified:16 Nov 2021 17:25

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