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Restructuring of amygdala subregion apportion across adolescence

Campbell, Claire E. and Mezher, Adam F. and Eckel, Sandrah P. and Tyszka, J. Michael and Pauli, Wolfgang M. and Nagel, Bonnie J. and Herting, Megan M. (2019) Restructuring of amygdala subregion apportion across adolescence. . (Unpublished)

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Total amygdala volumes continue to increase from childhood to young adulthood. Interestingly, postmortem studies have found postnatal neuron numbers increase in a nuclei specific fashion across development, suggesting amygdala maturation may involve changes to its composition. Thus, the goal of this study was to examine amygdala subregion apportionment in vivo and examine if these patterns were associated with age, sex, body mass index (BMI), and pubertal status in a large sample of typically developing adolescents (N=421, 44% female, ages 10-17 years). We utilized the CIT168 atlas to examine the relative volume fraction (RVF) of 9 subregions within each hemisphere of the amygdala. Generalized Additive Mixed Models (GAMM) were used to assess how demographic variables (e.g. age, sex) and physical development (e.g. BMI and pubertal status) were associated with amygdala RVFs. Results showed that age associations varied significantly by sex for the RVFs of the lateral (LA), basolateral ventral and paralaminar subdivision (BLVPL), central nucleus (CEN), and amygdala transition areas (ATA). While pubertal development was found to be associated with RVFs in the BLVPL, CEN, and ATA in males, best-fit model comparisons revealed that age was the best predictor of relative volumes of these subregions. These results suggest that the relative apportionment of the amygdala further develops with age in males across adolescence. These findings may help elucidate how sex differences could impact the prevalence of mental health disorders that arise during this adolescent period of development.

Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription Paper
Tyszka, J. Michael0000-0001-9342-9014
Pauli, Wolfgang M.0000-0002-0966-0254
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. bioRxiv preprint first posted online Jul. 9, 2019. The research above was supported by the following grants, R01 AA017664 (PI: Nagel), R21 MH099618 (PI: Nagel), R03 HD090308 (PI: Herting), K01 MH108761 (PI: Herting), and NIMH P50 MH094258 (PI: Adolphs). We also thank the families who contributed their time and participated in the above study. The authors have no conflicts of interest to disclose.
Funding AgencyGrant Number
NIHR01 AA017664
NIHR21 MH099618
NIHR03 HD090308
NIHK01 MH108761
NIHP50 MH094258
Record Number:CaltechAUTHORS:20190710-130706254
Persistent URL:
Official Citation:Restructuring of amygdala subregion apportion across adolescence. Claire E Campbell, Adam F Mezher, Sandrah P Eckel, Julian Michael Tyszka, Wolfgang M Pauli, Bonnie J Nagel, Megan M Herting. bioRxiv 690875; doi:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97031
Deposited By: Tony Diaz
Deposited On:10 Jul 2019 20:55
Last Modified:01 Jun 2020 16:38

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