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Restructuring of amygdala subregion apportion across adolescence

Campbell, Claire E. and Mezher, Adam F. and Eckel, Sandrah P. and Tyszka, J. Michael and Pauli, Wolfgang M. and Nagel, Bonnie J. and Herting, Megan M. (2021) Restructuring of amygdala subregion apportion across adolescence. Developmental Cognitive Neuroscience, 48 . Art. No. 100883. ISSN 1878-9293. PMCID PMC7820032. https://resolver.caltech.edu/CaltechAUTHORS:20190710-130706254

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Abstract

Total amygdala volumes develop in association with sex and puberty, and postmortem studies find neuronal numbers increase in a nuclei specific fashion across development. Thus, amygdala subregions and composition may evolve with age. Our goal was to examine if amygdala subregion absolute volumes and/or relative proportion varies as a function of age, sex, or puberty in a large sample of typically developing adolescents (N = 408, 43 % female, 10–17 years). Utilizing the in vivo CIT168 atlas, we quantified 9 subregions and implemented Generalized Additive Mixed Models to capture potential non-linear associations with age and pubertal status between sexes. Only males showed significant age associations with the basolateral ventral and paralaminar subdivision (BLVPL), central nucleus (CEN), and amygdala transition area (ATA). Again, only males showed relative differences in the proportion of the BLVPL, CEN, ATA, along with lateral (LA) and amygdalostriatal transition area (ASTA), with age. Using a best-fit modeling approach, age, and not puberty, was found to drive these associations. The results suggest that amygdala subregions show unique variations with age in males across adolescence. Future research is warranted to determine if our findings may contribute to sex differences in mental health that emerge across adolescence.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.dcn.2020.100883DOIArticle
https://doi.org/10.1101/690875DOIDiscussion Paper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820032PubMed CentralArticle
ORCID:
AuthorORCID
Campbell, Claire E.0000-0001-5288-9479
Mezher, Adam F.0000-0002-9317-1137
Eckel, Sandrah P.0000-0001-6050-7880
Tyszka, J. Michael0000-0001-9342-9014
Pauli, Wolfgang M.0000-0002-0966-0254
Nagel, Bonnie J.0000-0001-6339-7453
Herting, Megan M.0000-0002-0840-4582
Additional Information:© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. Received 28 May 2020, Revised 5 November 2020, Accepted 13 November 2020, Available online 11 December 2020. The research above was supported by the following grants, R01 AA017664 (PI: Nagel), R21 MH099618 (PI: Nagel), R03 HD090308 (PI: Herting), K01 MH108761 (PI: Herting), and NIMH P50 MH094258 #8198 (PI: Tyszka). We also thank the families who contributed their time and participated in the above study. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors have no conflict of interests to declare.
Funders:
Funding AgencyGrant Number
NIHR01 AA017664
NIHR21 MH099618
NIHR03 HD090308
NIHK01 MH108761
NIHP50 MH094258
Subject Keywords:Amygdala; Sex characteristics; Adolescent; Central amygdaloid nucleus; Basolateral nuclear complex; Corticomedial nuclear complex; Puberty
PubMed Central ID:PMC7820032
Record Number:CaltechAUTHORS:20190710-130706254
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190710-130706254
Official Citation:Claire E. Campbell, Adam F. Mezher, Sandrah P. Eckel, J. Michael Tyszka, Wolfgang M. Pauli, Bonnie J. Nagel, Megan M. Herting, Restructuring of amygdala subregion apportion across adolescence, Developmental Cognitive Neuroscience, Volume 48, 2021, 100883, ISSN 1878-9293, https://doi.org/10.1016/j.dcn.2020.100883. (http://www.sciencedirect.com/science/article/pii/S187892932030133X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97031
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jul 2019 20:55
Last Modified:01 Feb 2021 18:05

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