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Prenatal Exposure to Chlorinated Polyfluoroalkyl Ether Sulfonic Acids and Perfluoroalkyl Acids: Potential Role of Maternal Determinants and Associations with Birth Outcomes

Xu, Chenye and Yin, Shanshan and Liu, Yingxue and Chen, Fangfang and Zhong, Zhehui and Li, Fang and Liu, Kai and Liu, Weiping (2019) Prenatal Exposure to Chlorinated Polyfluoroalkyl Ether Sulfonic Acids and Perfluoroalkyl Acids: Potential Role of Maternal Determinants and Associations with Birth Outcomes. Journal of Hazardous Materials, 380 . Art. No. 120867. ISSN 0304-3894. https://resolver.caltech.edu/CaltechAUTHORS:20190712-100536781

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Abstract

Transplacental exposure to per/polyfluoroalkyl substances (PFASs) may impact fetal growth, but published evidence are still sparse and not in agreement. Moreover, little is known on the occurrence of emerging chlorinated polyfluorinated ether sulfonates (Cl-PFESAs, 6:2 and 8:2) in maternal-neonatal population. This study investigated eleven PFASs by analyzing 98 cord samples from Hangzhou, China. All target compounds can be transported across placenta, with highest median concentrations of 4.07, 1.05 and 0.731 ng/mL for PFOS, PFOA, and 6:2 Cl-PFESA. Older ages and higher pre-pregnancy BMI were associated with higher cord PFASs concentration; being primiparous was also significantly associated. Notably, after adjusting for potential confounders, PFOS was negatively associated with birth weight (β = -417.3 g, 95 % CI: -742.1, -92.4, p = 0.011, per a log10 unit increase in exposure) and ponderal index (β = -0.005 g/cm^3, 95 % CI: -0.008, -0.002, p = 0.000). PFOS and PFHxS were also indicated to be associated with small for gestational age birth (SGA) (p <  0.05). Although no evidence of association was observed between Cl-PFESAs and birth outcomes in this study, the bioaccumulative properties and development toxicity of Cl-PFESAs deserve continuous concern.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.jhazmat.2019.120867DOIArticle
ORCID:
AuthorORCID
Yin, Shanshan0000-0001-8859-9852
Liu, Kai0000-0002-2109-8196
Liu, Weiping0000-0002-1173-892X
Additional Information:© 2019 Published by Elsevier B.V. Received 31 December 2018, Revised 1 July 2019, Accepted 4 July 2019, Available online 11 July 2019.
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China21427815
National Natural Science Foundation of China21621005
Shanghai Sailing Program19YF1400500
Subject Keywords:per/polyfluoroalkyl substances; chlorinated polyfluorinated ether sulfonates; prenatal exposure; potential source identification; birth outcomes
Record Number:CaltechAUTHORS:20190712-100536781
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190712-100536781
Official Citation:Chenye Xu, Shanshan Yin, Yingxue Liu, Fangfang Chen, Zhehui Zhong, Fang Li, Kai Liu, Weiping Liu, Prenatal exposure to chlorinated polyfluoroalkyl ether sulfonic acids and perfluoroalkyl acids: Potential role of maternal determinants and associations with birth outcomes, Journal of Hazardous Materials, Volume 380, 2019, 120867, ISSN 0304-3894, https://doi.org/10.1016/j.jhazmat.2019.120867. (http://www.sciencedirect.com/science/article/pii/S0304389419308209)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97091
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Jul 2019 17:10
Last Modified:11 Oct 2019 19:43

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