A Caltech Library Service

Modeling vascular injury due to shock-induced bubble collapse in lithotripsy

Coralic, Vedran and Colonius, Tim (2014) Modeling vascular injury due to shock-induced bubble collapse in lithotripsy. In: 168th Meeting of the Acoustical Society of America, 27-31 October 2014, Indianapolis, IN.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Shock-induced collapse (SIC) of preexisting bubbles is investigated as a potential mechanism for vascular injury in shockwave lithotripsy (SWL). Preexisting bubbles exist under normal physiological conditions and grow larger and more numerous with ongoing treatment. We compute the three-dimensional SIC of a bubble using the multi-component Euler equations, and determine the resulting three-dimensional finite-strain deformation field in the material surrounding the collapsing bubble. We propose a criterion for vessel rupture and estimate the minimum bubble size, across clinical SWL pressures, which could result in rupture of microvasculature. Post-processing of the results and comparison to viscoelastic models for spherical bubble dynamics demonstrate that our results are insensitive to a wide range of estimated viscoelastic tissue properties during the collapse phase. During the jetting phase, however, viscoelastic effects are non-negligible. The minimum bubble size required to rupture a vessel is then estimated by adapting a previous model for the jet’s penetration depth as a function of tissue viscosity.

Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription ItemConference Site ItemConference Program
Colonius, Tim0000-0003-0326-3909
Additional Information:© 2014 Acoustical Society of America. Published Online: 23 October 2014.
Subject Keywords:Diseases and conditions; Fluid dynamics; Shock waves; Bubble dynamics; Viscoelastic effect; Medical diagnosis
Record Number:CaltechAUTHORS:20190712-112321008
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97103
Deposited By: Melissa Ray
Deposited On:15 Jul 2019 14:46
Last Modified:16 Nov 2021 17:26

Repository Staff Only: item control page