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Communication codes in developmental signaling pathways

Li, Pulin and Elowitz, Michael B. (2019) Communication codes in developmental signaling pathways. Development, 146 (12). Art. No. dev170977. ISSN 0950-1991. PMCID PMC6602343. https://resolver.caltech.edu/CaltechAUTHORS:20190718-110919202

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Abstract

A handful of core intercellular signaling pathways play pivotal roles in a broad variety of developmental processes. It has remained puzzling how so few pathways can provide the precision and specificity of cell-cell communication required for multicellular development. Solving this requires us to quantitatively understand how developmentally relevant signaling information is actively sensed, transformed and spatially distributed by signaling pathways. Recently, single cell analysis and cell-based reconstitution, among other approaches, have begun to reveal the ‘communication codes’ through which information is represented in the identities, concentrations, combinations and dynamics of extracellular ligands. They have also revealed how signaling pathways decipher these features and control the spatial distribution of signaling in multicellular contexts. Here, we review recent work reporting the discovery and analysis of communication codes and discuss their implications for diverse developmental processes.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1242/dev.170977DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6602343/PubMed CentralArticle
ORCID:
AuthorORCID
Elowitz, Michael B.0000-0002-1221-0967
Additional Information:© 2019 Published by The Company of Biologists Ltd. We thank L. Goentoro, J. Briscoe, A. Kicheva, S. Megason, A. Aulehla and E. Siggia for hepful discussion. We also thank C. L. Frick, N. Nandagopal, J. M. Linton, H. Klumpe, R. Kuintzle, L. Santat, R. Zhu and other members of the Elowitz lab for critical reading of the manuscript. The authors declare no competing or financial interests. The authors are supported by the Howard Hughes Medical Institute (M.B.E.) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Pathway to Independence Career Award (R00HD087532 to P.L.). Deposited in PMC for release after 12 months.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHR00HD087532
Subject Keywords:Communication codes, Signal processing, Pathway architecture
Issue or Number:12
PubMed Central ID:PMC6602343
Record Number:CaltechAUTHORS:20190718-110919202
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190718-110919202
Official Citation:Communication codes in developmental signaling pathways. Pulin Li, Michael B. Elowitz. Development 2019 146: dev170977 doi: 10.1242/dev.170977 Published 27 June 2019
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97231
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Jul 2019 21:10
Last Modified:03 Apr 2020 23:38

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