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Cavitation in shock wave lithotripsy

Bailey, Michael R. and Crum, Lawrence A. and Sapozhnikov, Oleg A. and Evan, Andrew P. and McAteer, James A. and Colonius, Tim and Cleveland, Robin O. (2003) Cavitation in shock wave lithotripsy. In: 146th Meeting of the Acoustical Society of America, 10-14 November 2003, Austin, TX.

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A case is presented for the important role of cavitation in stone comminution and tissue injury in shock wave lithotripsy (SWL). Confocal hydrophones and a coincidence algorithm were used to detect cavitation in kidney parenchyma. Elevated hydrostatic pressure dissolved cavitation nuclei and suppressed cell injury and stone comminution in vitro. A low‐insertion‐loss, thin, mylar film nearly eliminated stone erosion and crack formation only when in direct contact with the stone. This result indicates not only that cavitation is important in both cracking and erosion but also that bubbles act at the surface. Time inversion of the shock wave by use of a pressure‐release reflector reduced the calculated pressure at bubble collapse and the measured depth of bubble‐induced pits in aluminum. Correspondingly tissue injury in vivo was nearly eliminated. Cavitation was localized and intensified by the use of synchronously triggered, facing lithotripters. This dual pulse lithotripter enhanced comminution at its focus and reduced lysis in surrounding blood samples. The enhancement of comminution was lost when stones were placed in glycerol, which retarded bubble implosion. Thus, cavitation is important in comminution and injury and can be controlled to optimize efficacy and safety.

Item Type:Conference or Workshop Item (Paper)
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URLURL TypeDescription Program
Colonius, Tim0000-0003-0326-3909
Additional Information:© 2003 Acoustical Society of America. Published Online: 08 October 2003. Work supported by NIH DK43381, DK55674, and FIRCA.
Funding AgencyGrant Number
Fogarty International Research Collaboration AwardUNSPECIFIED
Subject Keywords:Diseases and conditions; Hydrostatics; Chemical elements; Hydrophone; Shock waves; Organic compounds; Crack formation; Medical diagnosis
Record Number:CaltechAUTHORS:20190718-165125458
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97250
Deposited By: Melissa Ray
Deposited On:22 Jul 2019 20:54
Last Modified:16 Nov 2021 17:30

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