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High-speed video microscopy and numerical modeling of bubble dynamics near a surface of urinary stone

Pishchalnikov, Yuri A. and Behnke-Parks, William M. and Schmidmayer, Kevin and Maeda, Kazuki and Colonius, Tim and Kenny, Thomas W. and Laser, Daniel J. (2019) High-speed video microscopy and numerical modeling of bubble dynamics near a surface of urinary stone. Journal of the Acoustical Society of America, 146 (1). pp. 516-531. ISSN 0001-4966. PMCID PMC6660306 . https://resolver.caltech.edu/CaltechAUTHORS:20190729-100946483

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Abstract

Ultra-high-speed video microscopy and numerical modeling were used to assess the dynamics of microbubbles at the surface of urinary stones. Lipid-shell microbubbles designed to accumulate on stone surfaces were driven by bursts of ultrasound in the sub-MHz range with pressure amplitudes on the order of 1 MPa. Microbubbles were observed to undergo repeated cycles of expansion and violent collapse. At maximum expansion, the microbubbles' cross-section resembled an ellipse truncated by the stone. Approximating the bubble shape as an oblate spheroid, this study modeled the collapse by solving the multicomponent Euler equations with a two-dimensional-axisymmetric code with adaptive mesh refinement for fine resolution of the gas-liquid interface. Modeled bubble collapse and high-speed video microscopy showed a distinctive circumferential pinching during the collapse. In the numerical model, this pinching was associated with bidirectional microjetting normal to the rigid surface and toroidal collapse of the bubble. Modeled pressure spikes had amplitudes two-to-three orders of magnitude greater than that of the driving wave. Micro-computed tomography was used to study surface erosion and formation of microcracks from the action of microbubbles. This study suggests that engineered microbubbles enable stone-treatment modalities with driving pressures significantly lower than those required without the microbubbles.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1121/1.5116693DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6660306/PubMed CentralArticle
ORCID:
AuthorORCID
Schmidmayer, Kevin0000-0003-0444-3098
Maeda, Kazuki0000-0002-5729-6194
Colonius, Tim0000-0003-0326-3909
Additional Information:© 2019 Acoustical Society of America. Received 4 March 2019; revised 21 June 2019; accepted 26 June 2019; published online 26 July 2019. We thank Dr. Marshall Stoller for valuable discussion, suggesting and arranging micro-CT, and for providing urinary stones, Dr. Sunita Ho for micro-CT of urinary stones, Dr. Ryoji Shiraki for chemical analysis of stone composition, Dr. Kyle Morrison (Sonic Concepts) for piezoelectric transducers, Dr. Matt Hopcroft for the development of the driving acoustic system and software for scanning of acoustic beams, David Bell for help with programming of the signal generator, and Todd Rumbaugh (Hadland Imaging) for advice on high-speed imaging. T.K. is a founding member of Applaud. Y.P., W.B.P., and D.L. are employees/investigators for Applaud. Experiments where performed at Applaud, the numerical modeling in Caltech. T.C. and K.S. acknowledge support from the Office of Naval Research (ONR, N0014-18-1-2625). T.C. and K.M. also acknowledge support from the ONR (N00014-17-1-2676) and the NIH (P01-DK043881).
Funders:
Funding AgencyGrant Number
Office of Naval Research (ONR)N0014-18-1-2625
Office of Naval Research (ONR)N00014-17-1-2676
NIHP01-DK043881
Issue or Number:1
PubMed Central ID:PMC6660306
Record Number:CaltechAUTHORS:20190729-100946483
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190729-100946483
Official Citation:High-speed video microscopy and numerical modeling of bubble dynamics near a surface of urinary stone. Yuri A. Pishchalnikov, William M. Behnke-Parks, Kevin Schmidmayer, Kazuki Maeda, Tim Colonius, Thomas W. Kenny, and Daniel J. Laser. The Journal of the Acoustical Society of America 146:1, 516-531; doi: 10.1121/1.5116693
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97483
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Jul 2019 17:17
Last Modified:18 Nov 2020 19:51

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