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Alternative mRNA splicing in cancer immunotherapy

Frankiw, Luke and Baltimore, David and Li, Guideng (2019) Alternative mRNA splicing in cancer immunotherapy. Nature Reviews. Immunology, 19 (11). pp. 675-687. ISSN 1474-1733. https://resolver.caltech.edu/CaltechAUTHORS:20190730-084832126

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Abstract

Immunotherapies are yielding effective treatments for several previously untreatable cancers. Still, the identification of suitable antigens specific to the tumour that can be targets for cancer vaccines and T cell therapies is a challenge. Alternative processing of mRNA, a phenomenon that has been shown to alter the proteomic diversity of many cancers, may offer the potential of a broadened target space. Here, we discuss the promise of analysing mRNA processing events in cancer cells, with an emphasis on mRNA splicing, for the identification of potential new targets for cancer immunotherapy. Further, we highlight the challenges that must be overcome for this new avenue to have clinical applicability.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41577-019-0195-7DOIArticle
https://rdcu.be/bMqZCPublisherFree ReadCube access
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Li, Guideng0000-0003-0840-7262
Additional Information:© 2019 Springer Nature Publishing AG. Accepted 02 July 2019; Published 30 July 2019. Preparation of this review was supported by an endowment provided by the Raymond and Beverly Sackler Foundation, the Parker Institute for Cancer Immunotherapy and the National Cancer Institute (grant 1U54 CA199090-01). Author Contributions: The authors contributed equally to all aspects of the article. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
Raymond and Beverly Sackler FoundationUNSPECIFIED
Parker Institute for Cancer ImmunotherapyUNSPECIFIED
NIH1U54 CA199090-01
National Cancer InstituteUNSPECIFIED
Subject Keywords:Immunotherapy; RNA
Issue or Number:11
Record Number:CaltechAUTHORS:20190730-084832126
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190730-084832126
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97508
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Jul 2019 15:54
Last Modified:29 Oct 2019 16:55

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