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Clinical neuroprosthetics: Today and tomorrow

Lee, Morgan B. and Kramer, Daniel R. and Peng, Terrance and Barbaro, Michael F. and Liu, Charles Y. and Kellis, Spencer and Lee, Brian (2019) Clinical neuroprosthetics: Today and tomorrow. Journal of Clinical Neuroscience, 68 . pp. 13-19. ISSN 0967-5868. PMCID PMC6717542. doi:10.1016/j.jocn.2019.07.056.

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Implantable neurostimulation devices provide a direct therapeutic link to the nervous system and can be considered brain-computer interfaces (BCI). Under this definition, BCI are not simply science fiction, they are part of existing neurosurgical practice. Clinical BCI are standard of care for historically difficult to treat neurological disorders. These systems target the central and peripheral nervous system and include Vagus Nerve Stimulation, Responsive Neurostimulation, and Deep Brain Stimulation. Recent advances in clinical BCI have focused on creating “closed-loop” systems. These systems rely on biomarker feedback and promise individualized therapy with optimal stimulation delivery and minimal side effects. Success of clinical BCI has paralleled research efforts to create BCI that restore upper extremity motor and sensory function to patients. Efforts to develop closed loop motor/sensory BCI is linked to the successes of today’s clinical BCI.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Kramer, Daniel R.0000-0003-4551-2977
Kellis, Spencer0000-0002-5158-1058
Additional Information:© 2019 Elsevier Ltd. Received 16 February 2019, Accepted 16 July 2019, Available online 30 July 2019.
Funding AgencyGrant Number
National Center for Advancing Translational SciencesUNSPECIFIED
Neurosurgery Research and Education FoundationUNSPECIFIED
PubMed Central ID:PMC6717542
Record Number:CaltechAUTHORS:20190730-095347924
Persistent URL:
Official Citation:Morgan B. Lee, Daniel R. Kramer, Terrance Peng, Michael F. Barbaro, Charles Y. Liu, Spencer Kellis, Brian Lee, Clinical neuroprosthetics: Today and tomorrow, Journal of Clinical Neuroscience, Volume 68, 2019, Pages 13-19, ISSN 0967-5868, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97513
Deposited By: Tony Diaz
Deposited On:30 Jul 2019 17:30
Last Modified:16 Nov 2021 17:32

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