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Mapping the oxysterol interactome

Ondrus, Alison E. (2019) Mapping the oxysterol interactome. In: 258th ACS National Meeting & Exposition, 25-29 August 2019, San Diego, CA.

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Oxysterols are signaling mols. that translate metabolic information to cellular response. In mammalian cells, oxysterols serve essential roles in transcriptional regulation, membrane integrity, and the activity of target proteins. Accordingly, oxysterols coordinate diverse events that include cholesterol biosynthesis, immune response, and viral infection and defense. Despite their potent effects, the structural code that dets. the specific activity of oxysterols remains uncharacterized. We have created a unique oxysterol scaffold that preserves the biophys. properties of the natural mols. and contains functional groups to covalently capture and identify cellular interactors. We describe the synthesis and characterization of one such mol. and demonstrate its capacity to recapitulate the activity of its natural congener within the Hedgehog signaling pathway. Our detailed biochem., transcriptional, and chemoproteomic studies define these probes as powerful tools to reveal how Nature templates function through metabolite structure.

Item Type:Conference or Workshop Item (Paper)
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Ondrus, Alison E.0000-0002-6023-3290
Additional Information:© 2019 American Chemical Society.
Record Number:CaltechAUTHORS:20190812-135907605
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97788
Deposited By: Tony Diaz
Deposited On:12 Aug 2019 21:01
Last Modified:25 Apr 2022 20:45

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