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Theory of Single Molecule Experiments of F_1-ATpase: Predictions, Tests and Comparison with Experiments

Volkán-Kacsó, Sándor and Marcus, Rudolph A. (2018) Theory of Single Molecule Experiments of F_1-ATpase: Predictions, Tests and Comparison with Experiments. In: Catalysis in Chemistry and Biology. World Scientific , Hackensack, NJ, pp. 285-294. ISBN 9789813237162.

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There is now a substantial body of single molecule experiments on biomolecular motors, supplementing the extensive structural and ensemble data on these systems. Our current focus is on the motor, F_1-ATPase, a component of the enzyme ATP Synthase that uses proton gradients to synthesize ATP. Our interest is in seeing what information single molecule studies may provide on the relation between structural changes and the rates of various processes involved in the ATP binding, release, hydrolysis and synthesis. Our approach is to utilize a class of kinetic-thermodynamic relations used for chemical reactions and originally coming from the field of electron and other transfer reactions. To adapt those relations to biomolecular motors we incorporated into the kinetic-thermodynamic free energy expressions an elastic interaction between the rotor and stator subunits of the motor, and coupled the rotor to the chemical and physical processes. The theory is aimed at adding insights to the different of rates in terms of protein structure. On the more technical side another aim is to relate one type of single molecule experiment to another and to ensemble experiments. Theory-based predictions are made and compared with experiment. Some of our recent PNAS studies are summarized, together with more recent results.

Item Type:Book Section
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Marcus, Rudolph A.0000-0001-6547-1469
Additional Information:© 2018 World Scientific Publishing Co Pte Ltd.
Record Number:CaltechAUTHORS:20190812-145045521
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Official Citation:THEORY OF SINGLE MOLECULE EXPERIMENTS OF F1-ATPASE: PREDICTIONS, TESTS AND COMPARISON WITH EXPERIMENTS. SÁNDOR VOLKÁN-KACSÓ and RUDOLPH A. MARCUS. Catalysis in Chemistry and Biology. August 2018, 285-294. doi: 10.1142/9789813237179_0041
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97796
Deposited By: Tony Diaz
Deposited On:09 Mar 2020 14:56
Last Modified:16 Nov 2021 17:34

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