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Human Insula Activation Reflects Risk Prediction Errors As Well As Risk

Preuschoff, Kerstin and Quartz, Steven R. and Bossaerts, Peter (2008) Human Insula Activation Reflects Risk Prediction Errors As Well As Risk. Journal of Neuroscience, 28 (11). pp. 2745-2752. ISSN 0270-6474. PMCID PMC6670675. https://resolver.caltech.edu/CaltechAUTHORS:20190819-074402997

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Abstract

Understanding how organisms deal with probabilistic stimulus-reward associations has been advanced by a convergence between reinforcement learning models and primate physiology, which demonstrated that the brain encodes a reward prediction error signal. However, organisms must also predict the level of risk associated with reward forecasts, monitor the errors in those risk predictions, and update these in light of new information. Risk prediction serves a dual purpose: (1) to guide choice in risk-sensitive organisms and (2) to modulate learning of uncertain rewards. To date, it is not known whether or how the brain accomplishes risk prediction. Using functional imaging during a simple gambling task in which we constantly changed risk, we show that an early-onset activation in the human insula correlates significantly with risk prediction error and that its time course is consistent with a role in rapid updating. Additionally, we show that activation previously associated with general uncertainty emerges with a delay consistent with a role in risk prediction. The activations correlating with risk prediction and risk prediction errors are the analogy for risk of activations correlating with reward prediction and reward prediction errors for reward expectation. As such, our findings indicate that our understanding of the neural basis of reward anticipation under uncertainty needs to be expanded to include risk prediction.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.4286-07.2008DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670675PubMed CentralArticle
ORCID:
AuthorORCID
Bossaerts, Peter0000-0003-2308-2603
Additional Information:© 2008 Society for Neuroscience. Received Sept. 19, 2007; revised Jan. 11, 2008; accepted Jan. 14, 2008. This work was supported by National Science Foundation Grant 0093757, the David and Lucile Packard Foundation, the Gordon and Betty Moore Foundation, and the Swiss Finance Institute. We thank members of the Social Cognitive Neuroscience Laboratory for helpful comments. We thank Steven Flaherty for technical assistance.
Funders:
Funding AgencyGrant Number
NSFBCS-0093757
David and Lucile Packard FoundationUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Swiss Finance InstituteUNSPECIFIED
Subject Keywords:risk prediction; insula; risk; uncertainty; reinforcement learning; reward prediction
Issue or Number:11
PubMed Central ID:PMC6670675
Record Number:CaltechAUTHORS:20190819-074402997
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190819-074402997
Official Citation:Human Insula Activation Reflects Risk Prediction Errors As Well As Risk. Kerstin Preuschoff, Steven R. Quartz, Peter Bossaerts. Journal of Neuroscience 12 March 2008, 28 (11) 2745-2752; DOI: 10.1523/JNEUROSCI.4286-07.2008
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:97990
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Aug 2019 21:01
Last Modified:03 Oct 2019 21:37

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