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Characterization of the brain functional architecture of psychostimulant withdrawal using single-cell whole brain imaging

Kimbrough, Adam and Smith, Lauren C. and Kallupi, Marsida and Simpson, Sierra and Collazo, Andres and George, Olivier (2019) Characterization of the brain functional architecture of psychostimulant withdrawal using single-cell whole brain imaging. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20190822-142447971

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Abstract

Numerous brain regions have been identified as contributing to addiction-like behaviors, but unclear is the way in which these brain regions as a whole lead to addiction. The search for a final common brain pathway that is involved in addiction remains elusive. To address this question, we used male C57BL/6J mice and performed single-cell whole-brain imaging of neural activity during withdrawal from cocaine, methamphetamine, and nicotine. We used hierarchical clustering and graph theory to identify similarities and differences in brain functional architecture. Although methamphetamine and cocaine shared some network similarities, the main common neuroadaptation between these psychostimulant drugs was a dramatic decrease in modularity, with a shift from a cortical- to subcortical-driven network, including a decrease in total hub brain regions. These results demonstrate that psychostimulant withdrawal produces the drug-dependent remodeling of functional architecture of the brain and suggest that the decreased modularity of brain functional networks and not a specific set of brain regions may represent the final common pathway that leads to addiction.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/743799DOIDiscussion Paper
ORCID:
AuthorORCID
Kimbrough, Adam0000-0001-9434-4987
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. bioRxiv preprint first posted online Aug. 22, 2019. This work was supported by National Institutes of Health grants DA044451, DA043799, DA047113, AA006420, AA020608, AA022977, AA027301, and AA007456, Tobacco-Related Disease Research Program grant 27IR-0047, and the Pearson Center for Alcoholism and Addiction Research. The authors would like to thank Michael Arends for editorial assistance with the manuscript. The authors declare no conflicts of interest. Code and data will be made available upon request. Author Contributions: A.K. and O.G. designed the research. A.K., A.C., L.C.S, M.K., and S.S. performed the experiments and collected the data. A.K. and L.C.S. designed the figures. A.K. analyzed the data. A.K. and O.G. wrote the manuscript. All of the authors read and approved the final manuscript.
Funders:
Funding AgencyGrant Number
NIHDA044451
NIHDA043799
NIHDA047113
NIHAA006420
NIHAA020608
NIHAA022977
NIHAA027301
NIHAA007456
California Tobacco-Related Disease Research Program27IR-0047
Pearson Center for Alcoholism and Addiction ResearchUNSPECIFIED
Record Number:CaltechAUTHORS:20190822-142447971
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190822-142447971
Official Citation:Characterization of the brain functional architecture of psychostimulant withdrawal using single-cell whole brain imaging. Adam Kimbrough, Lauren C Smith, Marsida Kallupi, Sierra Simpson, Andres Collazo, Olivier George. bioRxiv 743799; doi: https://doi.org/10.1101/743799
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98131
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Aug 2019 21:35
Last Modified:03 Oct 2019 21:38

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