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Progress Towards Patient-Specific Computational Flow Modeling of the Left Heart via Combination of Magnetic Resonance Imaging with Computational Fluid Dynamics

Saber, Nikoo R. and Wood, Nigel B. and Gosman, A. D. and Merrifield, Robert D. and Yang, Guang-Zhong and Charrier, Clare L. and Gatehouse, Peter D. and Firmin, David N. (2003) Progress Towards Patient-Specific Computational Flow Modeling of the Left Heart via Combination of Magnetic Resonance Imaging with Computational Fluid Dynamics. Annals of Biomedical Engineering, 31 (1). pp. 42-52. ISSN 0090-6964. https://resolver.caltech.edu/CaltechAUTHORS:20190823-105107482

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Abstract

A combined computational fluid dynamics (CFD) and magnetic resonance imaging (MRI) methodology has been developed to simulate blood flow in a subject-specific left heart. The research continues from earlier experience in modeling the human left ventricle using time-varying anatomical MR scans. Breathing artifacts are reduced by means of a MR navigator echo sequence with feedback to the subject, allowing a near constant breath-hold diaphragm position. An improved interactive segmentation technique for the long- and short-axis anatomical slices is used. The computational domain is extended to include the proximal left atrium and ascending aorta as well as the left ventricle, and the mitral and aortic valve orifices are approximately represented. The CFD results show remarkable correspondence with the MR velocity data acquired for comparison purposes, as well as with previously published in vivo experiments (velocity and pressure). Coherent vortex formation is observed below the mitral valve, with a larger anterior vortex dominating the late-diastolic phases. Some quantitative discrepancies exist between the CFD and MRI flow velocities, owing to the limitations of the MR dataset in the valve region, heart rate differences in the anatomical and velocity acquisitions, and to certain phenomena that were not simulated. The CFD results compare well with measured ranges in literature.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1114/1.1533073DOIArticle
https://rdcu.be/bPnBZPublisherFree ReadCube access
Additional Information:© Biomedical Engineering Society 2003. (Received 19 July 2001; accepted 14 October 2002) The authors appreciate the generous support from the British Heart Foundation under Grant No. PG/97049. The segmentation and reconstruction scheme is included in the CMRTools© software. The second order interpolation scheme was developed in consultation with H. Weller at Imperial College.
Group:GALCIT
Funders:
Funding AgencyGrant Number
British Heart FoundationPG/97049
Subject Keywords:Blood flow simulation, MRI measurements, Left ventricle, Flow structure, Experimental comparisons
Issue or Number:1
Record Number:CaltechAUTHORS:20190823-105107482
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190823-105107482
Official Citation:Saber, N.R., Wood, N.B., Gosman, A.D. et al. Annals of Biomedical Engineering (2003) 31: 42. https://doi.org/10.1114/1.1533073
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98168
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:23 Aug 2019 19:40
Last Modified:03 Oct 2019 21:38

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