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Neural Dynamics in Monkey Parietal Reach Region Reflect Context-Specific Sensorimotor Transformations

Gail, Alexander and Andersen, Richard A. (2006) Neural Dynamics in Monkey Parietal Reach Region Reflect Context-Specific Sensorimotor Transformations. Journal of Neuroscience, 26 (37). pp. 9376-9384. ISSN 0270-6474. PMCID PMC6674591. https://resolver.caltech.edu/CaltechAUTHORS:20190826-075340134

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Abstract

We investigated the neural dynamics of sensorimotor transformations in the parietal reach region (PRR) of monkeys. To dissociate sensory from motor goal representations, we used a memory-guided anti-reach task. The monkeys had to reach either to a visually instructed, memorized peripheral target position (pro-reach) or to a diametrically opposed position (anti) while keeping central ocular fixation. Pro- and anti-reaches were randomly interleaved and indicated by a color instruction from the beginning of each trial. We analyzed spatiotemporal single-cell tuning and performed time-resolved population decoding to quantify the dynamic representation of the spatial visual cue, the reach goal, and the currently valid task rule (pro/anti mapping). Sensory information regarding the visual cue position was represented weakly during a short period of cue visibility. PRR predominantly encoded the reach goal from the end of the cue period on. The representation of the reach goal in the memory task evolves later for the anti- compared with pro-reaches, consistent with a 40–50 ms difference in reaction time between the two task rules. The task rule could be decoded before the appearance of the spatial cue, which indicates that abstract rule information is present in PRR that is independent of spatial cue or motor goal representations. Our findings support the hypothesis that PRR immediately translates current sensory information into reach movement plans, rather than storing the memorized cue location in the instructed-delay task. This finding indicates that PRR represents integrated knowledge on spatial sensory information combined with abstract behavioral rules to encode the desired movement goal.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.1570-06.2006DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674591PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2006 Society for Neuroscience. Received April 11, 2006; revised July 26, 2006; accepted July 27, 2006. This work was supported by the National Institutes of Health, Defense Advanced Research Projects Agency, and Office of Naval Research. We thank Axel Lindner, Marina Brozovic, and Sam Musallam for valuable comments on a previous draft of this manuscript, K. Pejsa, N. Sammons, and L. Martel for animal care, and T. Yao and V. Shcherbatyuk for administrative and technical support.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Subject Keywords:sensorimotor transformation; posterior parietal cortex; motor intention; goal-directed behavior; anti-reach; S–R compatibility
Issue or Number:37
PubMed Central ID:PMC6674591
Record Number:CaltechAUTHORS:20190826-075340134
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190826-075340134
Official Citation:Neural Dynamics in Monkey Parietal Reach Region Reflect Context-Specific Sensorimotor Transformations. Alexander Gail, Richard A. Andersen. Journal of Neuroscience 13 September 2006, 26 (37) 9376-9384; DOI: 10.1523/JNEUROSCI.1570-06.2006
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98201
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Aug 2019 16:11
Last Modified:03 Oct 2019 21:38

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