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Congener-specific Mother-Fetus Distribution, Placental Retention, and Transport of C_(10-13) and C_(14-17) Chlorinated Paraffins in Pregnant Women

Aamir, Muhammad and Yin, Shanshan and Guo, Fangjie and Liu, Kai and Xu, Chenye and Liu, Weiping (2019) Congener-specific Mother-Fetus Distribution, Placental Retention, and Transport of C_(10-13) and C_(14-17) Chlorinated Paraffins in Pregnant Women. Environmental Science and Technology, 53 (19). pp. 11458-11466. ISSN 0013-936X. https://resolver.caltech.edu/CaltechAUTHORS:20190827-100104861

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Abstract

Short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) are high-production-volume persistent and toxic industrial chemicals found ubiquitously in various environmental matrices. However, information is scarce regarding human internal exposure. The congener-specific SCCP and MCCP levels in matched maternal serum (n = 31), umbilical cord serum (n = 31), and placenta (n = 31) were studied to investigate the maternal–placenta–fetus distribution and the placental transport mechanisms of SCCPs and MCCPs. The results indicated that lower chlorinated and shorter carbon chain CPs were efficiently transported across placenta compared to highly chlorinated and longer carbon chain CPs. Meanwhile, ∑MCCP concentration followed the order of maternal sera > placentas > cord sera. The cord/maternal concentration fraction ratios (R_(CM)) of CPs exhibited similar values from C_(10) to C_(14), and then from C_(15), a decreasing trend was observed with increasing carbon chain length. The log-normalized maternal SCCP concentrations were positively correlated (P < 0.01) with that in the cord, suggesting fetus exposure to SCCPs during pregnancy. Furthermore, the placenta/maternal concentration fraction ratio (R_(PM)) values for MCCPs were relatively higher than those for SCCPs, demonstrating that MCCPs were not efficiently transported and effectively retained in placenta tissues. These findings provide a better understanding of the maternal–fetal transmission and neonatal exposure to CPs.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acs.est.9b02116DOIArticle
ORCID:
AuthorORCID
Aamir, Muhammad0000-0003-0579-5757
Yin, Shanshan0000-0001-8859-9852
Liu, Kai0000-0002-2109-8196
Liu, Weiping0000-0002-1173-892X
Alternate Title:Congener-specific Mother-Fetus Distribution, Placental Retention, and Transport of C10-13 and C14-17 Chlorinated Paraffins in Pregnant Women
Additional Information:© 2019 American Chemical Society. Received: April 8, 2019; Revised: August 15, 2019; Accepted: August 27, 2019; Published: August 27, 2019. This work was jointly supported by the National Natural Science Foundation of China (Nos. 21427815, 21777137) and the Creative Research Group Fund (No. 21621005). We thank the medical staff at the Wuhan No. 1 Hospital for collecting the maternal serum, cord serum, and placenta samples. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China21427815
National Natural Science Foundation of China21777137
National Natural Science Foundation of China21621005
Issue or Number:19
Record Number:CaltechAUTHORS:20190827-100104861
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190827-100104861
Official Citation:Congener-Specific Mother–Fetus Distribution, Placental Retention, and Transport of C10–13 and C14–17 Chlorinated Paraffins in Pregnant Women. Muhammad Aamir, Shanshan Yin, Fangjie Guo, Kai Liu, Chenye Xu, and Weiping Liu. Environmental Science & Technology 2019 53 (19), 11458-11466 DOI: 10.1021/acs.est.9b02116
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98264
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Aug 2019 17:23
Last Modified:03 Oct 2019 21:39

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