Cook, Colin and Komatsu, Hirotake and Salgado, Mayra and Mullen, Yoko and Kandeel, Fouad and Tai, Yu-Chong (2019) MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability. In: 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE , Piscataway, NJ, pp. 2221-2224. ISBN 9781538681046. https://resolver.caltech.edu/CaltechAUTHORS:20190829-100210762
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Abstract
This paper reports on the first MEMS silicon cutters designed to rapidly section donor pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts during the critical period of re-implantation and revascularization by the host. The monolithic silicon chips feature an array of spaced nano-sharp (r < 100 nm) blades that cleanly section islet tissue. This work represents the first time that sectioning of pancreatic islets has been proposed and validated as a means to overcome the well-known problems of hypoxia and core-necrosis that is encountered in current islet transplantation procedures.
| Item Type: | Book Section | ||||||||
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| Additional Information: | © 2019 IEEE. Thanks to members of the MEMS lab for their help with this work, notably Trevor Roper, Christine Garske, and Nicholas Scianmarello. We would also like to thank the Caltech-City of Hope Biomedical Research Initiative for funding this project. | ||||||||
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| Subject Keywords: | Diabetes, islets, oxygen, cutter, sectioning, silicon, hypoxia, MEMS, viability, diffusion | ||||||||
| Record Number: | CaltechAUTHORS:20190829-100210762 | ||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190829-100210762 | ||||||||
| Official Citation: | C. Cook, H. Komatsu, M. Salgado, Y. Mullen, F. Kandeel and Y. Tai, "MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability," 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), Berlin, Germany, 2019, pp. 2221-2224. doi: 10.1109/TRANSDUCERS.2019.8808431 | ||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
| ID Code: | 98332 | ||||||||
| Collection: | CaltechAUTHORS | ||||||||
| Deposited By: | George Porter | ||||||||
| Deposited On: | 30 Aug 2019 15:12 | ||||||||
| Last Modified: | 03 Oct 2019 21:40 |
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