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MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability

Cook, Colin and Komatsu, Hirotake and Salgado, Mayra and Mullen, Yoko and Kandeel, Fouad and Tai, Yu-Chong (2019) MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability. In: 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE , Piscataway, NJ, pp. 2221-2224. ISBN 9781538681046. https://resolver.caltech.edu/CaltechAUTHORS:20190829-100210762

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Abstract

This paper reports on the first MEMS silicon cutters designed to rapidly section donor pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts during the critical period of re-implantation and revascularization by the host. The monolithic silicon chips feature an array of spaced nano-sharp (r < 100 nm) blades that cleanly section islet tissue. This work represents the first time that sectioning of pancreatic islets has been proposed and validated as a means to overcome the well-known problems of hypoxia and core-necrosis that is encountered in current islet transplantation procedures.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/transducers.2019.8808431DOIArticle
ORCID:
AuthorORCID
Cook, Colin0000-0002-6283-5105
Komatsu, Hirotake0000-0003-0876-4809
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2019 IEEE. Thanks to members of the MEMS lab for their help with this work, notably Trevor Roper, Christine Garske, and Nicholas Scianmarello. We would also like to thank the Caltech-City of Hope Biomedical Research Initiative for funding this project.
Funders:
Funding AgencyGrant Number
Caltech-City of Hope Biomedical InitiativeUNSPECIFIED
Subject Keywords:Diabetes, islets, oxygen, cutter, sectioning, silicon, hypoxia, MEMS, viability, diffusion
Record Number:CaltechAUTHORS:20190829-100210762
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190829-100210762
Official Citation:C. Cook, H. Komatsu, M. Salgado, Y. Mullen, F. Kandeel and Y. Tai, "MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability," 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), Berlin, Germany, 2019, pp. 2221-2224. doi: 10.1109/TRANSDUCERS.2019.8808431
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98332
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Aug 2019 15:12
Last Modified:03 Oct 2019 21:40

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