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Dual-Function Intravascular Catheter for Atherosclerosis Diagnostics

Luo, Yuan and Abiri, Parinaz and Packard, Rene R. S. and Hsiai, Tzung K. and Tai, Yu-Chong (2019) Dual-Function Intravascular Catheter for Atherosclerosis Diagnostics. In: 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE , Piscataway, NJ, pp. 625-628. ISBN 9781538681046.

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We herein present a novel intravascular catheter, with dual-functions of electrical impedance spectroscopy (EIS) and flow fraction reserve (FFR), validated in live pig animal for atherosclerosis/plaques diagnostics. FFR has been the standard tool in determining plaque vulnerability yet could produce false negative results when stenosis is relatively small. Meanwhile, EIS has been demonstrated to specifically distinguish the lipid-rich pool, the signifying feature of rupture-prone plaques. The synergetic performance of these two functionalities can significantly enhance state-of-art diagnostics accuracy for atherosclerosis.

Item Type:Book Section
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URLURL TypeDescription
Packard, Rene R. S.0000-0002-8520-5843
Hsiai, Tzung K.0000-0003-1734-0792
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2019 IEEE. This study was supported by National Institutes of Health grants HL118650 (T.K.H., Y.C.T.), HL083015 (T.K.H.), HL111437 (T.K.H., Y.C.T.). The authors also want to thank colleagues from Caltech MEMS Lab and Cardiovascular Engineering Lab in UCLA for their kind help and fruitful discussion throughout this work.
Funding AgencyGrant Number
Subject Keywords:Atherosclerosis, Intravascular detection, Fractional Flow Reserve, Electrochemical Impedance Spectroscopy
Record Number:CaltechAUTHORS:20190829-100211037
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Official Citation:Y. Luo, P. Abiri, R. R. S. Packard, T. K. Hsiai and Y. Tai, "Dual-Function Intravascular Catheter for Atherosclerosis Diagnostics," 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), Berlin, Germany, 2019, pp. 625-628. doi: 10.1109/TRANSDUCERS.2019.8808540
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98335
Deposited By: George Porter
Deposited On:30 Aug 2019 15:23
Last Modified:16 Nov 2021 17:38

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