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The Process of Infection with Bacteriophage øX174 XIII. Evidence for an Essential Bacterial "Site"

Yarus, Michael J. and Sinsheimer, Robert L. (1967) The Process of Infection with Bacteriophage øX174 XIII. Evidence for an Essential Bacterial "Site". Journal of Virology, 1 (1). pp. 135-144. ISSN 0021-8979. PMCID PMC375514. http://resolver.caltech.edu/CaltechAUTHORS:YARjvir67

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Abstract

The burst of a starved bacterium infected with several øX174 bacteriophage was usually found to contain genetic traits of only one of the possible parents; less often, two phage multiplied in the same host cell. Unstarved cells, in contrast, supported the growth of at least four parental phage types. The unproductive phage seemed to be able to undergo the intracellular transition from parental single-stranded deoxyribonucleic acid to the double-stranded "replicative form" (RF). These results are taken to mean that some bacterial factor required for a step between RF synthesis and maturation of progeny is limited in starved cells.


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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375514/PubMed CentralArticle
Additional Information:© 1967 American Society for Microbiology. Received for publication 31 October 1966. This investigation was supported by Public Health Service grants RG6965 and GM13554. C.A. Hutchison III supplied several of the φX mutants used in this work, and we thank him both for these and for many helpful discussions. David Denhardt collaborated in the experiment represented in Fig. 1. From a thesis submitted by M. Yarus to the California Institute of Technology in partial fulfillment of the requirements for the Ph.D. degree. http://resolver.caltech.edu/CaltechETD:etd-09232002-152158
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Funding AgencyGrant Number
NIHRG6965
NIHGM13554
PubMed Central ID:PMC375514
Record Number:CaltechAUTHORS:YARjvir67
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:YARjvir67
Alternative URL:http://jvi.asm.org/cgi/content/abstract/1/1/135
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9838
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:20 Mar 2008
Last Modified:05 Apr 2017 17:56

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