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Target Selection Signals for Arm Reaching in the Posterior Parietal Cortex

Scherberger, Hansjörg and Andersen, Richard A. (2007) Target Selection Signals for Arm Reaching in the Posterior Parietal Cortex. Journal of Neuroscience, 27 (8). pp. 2001-2012. ISSN 0270-6474. PMCID PMC6673534. https://resolver.caltech.edu/CaltechAUTHORS:20190903-074737014

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Abstract

The selection of visual stimuli as a target for a motor action may depend on external as well as internal variables. The parietal reach region (PRR) in the posterior parietal cortex plays an important role in the transformation of visual information into reach movement plans. We asked how neurons in PRR of macaque monkeys reflect the decision process of selecting one of two visual stimuli as a target for a reach movement. Spiking activity was recorded while the animal performed a free-choice task with one target presented in the preferred direction and the other in the off direction of the cell. Stimulus-onset asynchrony (SOA) was adjusted to ensure that both targets were selected equally often and the amount of reward was fixed. Neural activity in PRR was action specific for arm reaching and reflected the timing of the SOA as well as the selection of reach targets. In individual trials, activity was strongly linked to the choice of the animal, and, for the majority of cells, target selections could be predicted from activity in the stimulation or planning period, i.e., before the movement started. Many neurons were gain modulated by the fixation position, but gain modulation did not influence the target selection process directly. Finally, it was found that target selection for saccade movements was only weakly represented in PRR. These findings suggest that PRR is involved in decision making for reach movements and that separate cortical networks exist for target selection of different types of action.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.4274-06.2007DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673534PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2007 Society for Neuroscience. Received Jan. 3, 2006; revised Jan. 10, 2007; accepted Jan. 10, 2007. This work was supported by the Christopher Reeve Paralysis Foundation, the James G. Boswell Foundation, Defense Advanced Research Projects Agency, Office of Naval Research, Sloan-Swartz Center for Theoretical Neurobiology at the California Institute of Technology, and the National Eye Institute. We thank B. G. Grieve, K. Pejsa, and L. Martel for animal care, T. Yao and C. Marks for administrative assistance, and V. Shcherbatyuk for technical support.
Funders:
Funding AgencyGrant Number
Christopher Reeve Paralysis FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Sloan-Swartz Center for Theoretical NeurobiologyUNSPECIFIED
National Eye InstituteUNSPECIFIED
NIHHD-05753
Subject Keywords:sensorimotor transformation; motor system; movement planning; decision making; monkey; parietal reach region
Issue or Number:8
PubMed Central ID:PMC6673534
Record Number:CaltechAUTHORS:20190903-074737014
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190903-074737014
Official Citation:Target Selection Signals for Arm Reaching in the Posterior Parietal Cortex. Hansjörg Scherberger, Richard A. Andersen. Journal of Neuroscience 21 February 2007, 27 (8) 2001-2012; DOI: 10.1523/JNEUROSCI.4274-06.2007
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98380
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Sep 2019 16:12
Last Modified:03 Oct 2019 21:40

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