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Mechanism of Ruthenium Based Olefin Metathesis Catalysts

Grubbs, R. H. and Sanford, M. (2002) Mechanism of Ruthenium Based Olefin Metathesis Catalysts. In: Ring Opening Metathesis Polymerisation and Related Chemistry: State of the Art and Visions for the New Century. NATO Science Series II. No.56. Springer Netherlands , Dordrecht, pp. 17-21. ISBN 9781402005596.

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Over the past decade, olefin metathesis has emerged as a powerful method for the formation of carbon-carbon double bonds [1]. In particular, two ruthenium-based catalysts - (PCy_3)_2(Cl)_2Ru=CHPh (1) [2] and IMesH_2(PCY_3)(Cl)_2Ru=CHPh (2) [3] [IMesH_2 = 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene] (Figure 1) - have become important tools for organic and polymer chemists due to their reactivity with olefinic substrates in the presence of most common functional groups [4]. The development of the "second generation" catalyst 2 is especially significant, since this complex shows extremely high activity for olefin metathesis reactions, often comparing favorably to early transition metal catalyst systems without the complications of functional group incompatibility [5]. Catalyst 2 has recently been applied to the preparation of highly functionalized [6] and tri- and tetra- substituted [3] olefins in small molecule substrates (Figure 2). In addition, 2 has proven useful for the ring opening metathesis polymerization of ROD substituted norbomenes (RGD = peptide) to produce bio-active polymers (Figure 2) [7].

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Grubbs, R. H.0000-0002-0057-7817
Additional Information:© Springer Science+Business Media Dordrecht 2002.
Subject Keywords:Ethyl Vinyl; Acyclic Diene Metathesis Polymerization; Olefin Metathesis; Ring Open Metathesis Polymerization; Ethyl Vinyl Ether
Series Name:NATO Science Series II
Issue or Number:56
Record Number:CaltechAUTHORS:20190909-133031358
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98524
Deposited By: George Porter
Deposited On:09 Sep 2019 22:16
Last Modified:16 Nov 2021 17:39

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