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Single-shot quantitative phase gradient microscopy using a system of multifunctional metasurfaces

Kwon, Hyounghan and Arbabi, Ehsan and Kamali, Seyedeh Mahsa and Faraji-Dana, MohammadSadegh and Faraon, Andrei (2020) Single-shot quantitative phase gradient microscopy using a system of multifunctional metasurfaces. Nature Photonics, 14 (2). pp. 109-114. ISSN 1749-4885. https://resolver.caltech.edu/CaltechAUTHORS:20190913-094942952

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Abstract

Quantitative phase imaging (QPI) of transparent samples plays an essential role in multiple biomedical applications, and miniaturizing these systems will enable their adoption into point-of-care and in vivo applications. Here, we propose a compact quantitative phase gradient microscope (QGPM) based on two dielectric metasurface layers, inspired by a classical differential interference contrast (DIC) microscope. Owing to the multifunctionality and compactness of the dielectric metasurfaces, the QPGM simultaneously captures three DIC images to generate a quantitative phase gradient image in a single shot. The volume of the metasurface optical system is on the order of 1 mm³. Imaging experiments with various phase resolution samples verify the capability to capture quantitative phase gradient data, with phase gradient sensitivity better than 92.3 mrad μm⁻¹ and single-cell resolution. The results showcase the potential of metasurfaces for developing miniaturized QPI systems for label-free cellular imaging and point-of-care devices.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41566-019-0536-xDOIArticle
https://rdcu.be/b0SdwPublisherFree ReadCube access
ORCID:
AuthorORCID
Arbabi, Ehsan0000-0002-5328-3863
Kamali, Seyedeh Mahsa0000-0002-6968-811X
Faraon, Andrei0000-0002-8141-391X
Additional Information:© 2019 Springer Nature Limited. Received 22 March 2019; Accepted 13 September 2019; Published 28 October 2019. This work was supported by the Caltech Innovation Initiative programe. The device nanofabrication was performed at the Kavli Nanoscience Institute at Caltech. We thank C. Choi and C. Yang for Fourier ptychography microscope measurements and helpful discussions. H.K. acknowledges a fellowship from Ilju organization. Data availability: The data that support the findings of this study are available from the corresponding author upon request. Author Contributions: H.K. and A.F. conceived the project. H.K., E.A., S.M.K. and M.F.-D. designed and fabricated the samples. H.K. performed the simulations and measurements. H.K., E.A., S.M.K. and M.F. analysed the data. H.K., E.A. and A.F. co-wrote the manuscript. All authors discussed the results and commented on the manuscript. Competing interests: H.K., E.A. and A.F. have submitted a patent application based on the idea presented in this work.
Group:Kavli Nanoscience Institute
Funders:
Funding AgencyGrant Number
Caltech Innovation Initiative (CI2)UNSPECIFIED
Ilju OrganizationUNSPECIFIED
Subject Keywords:Imaging and sensing; Integrated optics; Metamaterials; Microscopy
Issue or Number:2
Record Number:CaltechAUTHORS:20190913-094942952
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190913-094942952
Official Citation:Kwon, H., Arbabi, E., Kamali, S.M. et al. Single-shot quantitative phase gradient microscopy using a system of multifunctional metasurfaces. Nat. Photonics 14, 109–114 (2020). https://doi.org/10.1038/s41566-019-0536-x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98639
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:28 Oct 2019 17:30
Last Modified:28 Jan 2020 18:51

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