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Robotics in the Gut

Min, Jihong and Yang, Yiran and Wu, Zhiguang and Gao, Wei (2020) Robotics in the Gut. Advanced Therapeutics, 3 (4). Art. No. 1900125. ISSN 2366-3987.

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Since the advent of ingestible temperature sensors and capsule endoscopes, rapid advances in electronics, robotics, nanotechnology, and material sciences have opened the door for the development of novel medical ingestible robots. The untethered robots provide direct, non‐invasive access to the entire gastrointestinal (GI) tract. Furthermore, the tissues, gases, and fluids of the gastrointestinal lumen contain a multitude of biomarkers indicative of gut diseases and health. Ingestible medical robots equipped with advanced imaging and sensing techniques can enable the diagnosis and monitoring of diseases, while providing a better pathophysiological understanding of gastrointestinal disorders. In addition, various robotic actuation mechanisms in the macro‐ and microscale can realize enhanced drug delivery and surgical interventions for the treatment of diseases. In this paper, an overview of recent advances in ingestible robots toward imaging, sensing, drug delivery, and surgical applications in the GI tract is provided. Key challenges and strategies for the development of novel ingestible robots and future directions of ingestible robots toward precision medicine are also discussed.

Item Type:Article
Related URLs:
URLURL TypeDescription
Min, Jihong0000-0002-5788-1473
Yang, Yiran0000-0001-8770-8746
Gao, Wei0000-0002-8503-4562
Additional Information:© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Issue Online: 17 April 2020; Version of Record online: 17 September 2019; Manuscript revised: 13 August 2019; Manuscript received: 30 June 2019. This work was sponsored by the startup funds from California Institute of Technology (Caltech), the Donna and Benjamin M. Rosen Bioengineering Center at Caltech, and Caltech—City of Hope Biomedical Research Initiative. The authors declare no conflict of interest.
Group:Rosen Bioengineering Center
Funding AgencyGrant Number
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Caltech-City of Hope Biomedical InitiativeUNSPECIFIED
Subject Keywords:capsule endoscopy; drug delivery; gastrointestinal tract; robotics; sensors
Issue or Number:4
Record Number:CaltechAUTHORS:20190917-132535911
Persistent URL:
Official Citation:Min, J., Yang, Y., Wu, Z. and Gao, W. (2020), Robotics in the Gut. Adv. Therap., 3: 1900125. doi:10.1002/adtp.201900125
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98678
Deposited By: Tony Diaz
Deposited On:17 Sep 2019 21:47
Last Modified:19 Nov 2020 22:58

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