Fasan, Rudi and Kan, S. B. Jennifer and Zhao, Huimin (2019) A Continuing Career in Biocatalysis: Frances H. Arnold. ACS Catalysis, 9 (11). pp. 9775-9788. ISSN 2155-5435. PMCID PMC7390471. doi:10.1021/acscatal.9b02737. https://resolver.caltech.edu/CaltechAUTHORS:20190917-160539760
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Abstract
On the occasion of Professor Frances H. Arnold’s recent acceptance of the 2018 Nobel Prize in Chemistry, we honor her numerous contributions to the fields of directed evolution and biocatalysis. Arnold pioneered the development of directed evolution methods for engineering enzymes as biocatalysts. Her highly interdisciplinary research has provided grounds not only for understanding the mechanisms of enzyme evolution but also for developing commercially viable enzyme biocatalysts and biocatalytic processes. In this Account, we highlight some of her notable contributions in the past three decades in the development of foundational directed evolution methods and their applications in the design and engineering of enzymes with desired functions for biocatalysis. Her work has created a paradigm shift in the broad catalysis field.
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| Additional Information: | © 2019 American Chemical Society. Received: June 29, 2019; Revised: August 21, 2019; Published: September 17, 2019. This work was supported by the U.S. National Science Foundation (CHE-1609550 grant to R.F.), the Rothenberg Innovation Initiative (RI2) Program and Jacobs Institute for Molecular Engineering for Medicine at Caltech (S.B.J.K.), the U.S. Department of Energy (DE-SC0018260 and DE-SC0018420 grants to H.Z.), and the U.S. National Institutes of Health (R01GM098628 grant to R.F.; AI144967 grant to H.Z.). The authors declare no competing financial interest. | ||||||||||||||||
| Group: | Jacobs Institute for Molecular Engineering for Medicine | ||||||||||||||||
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| Subject Keywords: | directed evolution, biocatalysis, enzyme engineering, P450s, abiological functions, carbene transfer reactions, nitrene transfer reactions, C–H functionalization | ||||||||||||||||
| Issue or Number: | 11 | ||||||||||||||||
| PubMed Central ID: | PMC7390471 | ||||||||||||||||
| DOI: | 10.1021/acscatal.9b02737 | ||||||||||||||||
| Record Number: | CaltechAUTHORS:20190917-160539760 | ||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190917-160539760 | ||||||||||||||||
| Official Citation: | A Continuing Career in Biocatalysis: Frances H. Arnold. Rudi Fasan, S. B. Jennifer Kan, and Huimin Zhao. ACS Catalysis 2019 9 (11), 9775-9788. DOI: 10.1021/acscatal.9b02737 | ||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||
| ID Code: | 98702 | ||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||||||
| Deposited On: | 17 Sep 2019 23:13 | ||||||||||||||||
| Last Modified: | 12 Feb 2022 00:34 |
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