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Precise sequence complementarity between yeast chromosome ends and two classes of just-subtelomeric sequences

Britten, Roy J. (1998) Precise sequence complementarity between yeast chromosome ends and two classes of just-subtelomeric sequences. Proceedings of the National Academy of Sciences of the United States of America, 95 (11). pp. 5906-5912. ISSN 0027-8424. PMCID PMC34494.

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The terminal regions (last 20 kb) of Saccharomyces cerevisiae chromosomes universally contain blocks of precise sequence similarity to other chromosome terminal regions. The left and right terminal regions are distinct in the sense that the sequence similarities between them are reverse complements. Direct sequence similarity occurs between the left terminal regions and also between the right terminal regions, but not between any left ends and right ends. With minor exceptions the relationships range from 80% to 100% match within blocks. The regions of similarity are composites of familiar and unfamiliar repeated sequences as well as what could be considered "single-copy" (or better "two-copy") sequences. All terminal regions were compared with all other chromosomes, forward and reverse complement, and 768 comparisons are diagrammed. It appears there has been an extensive history of sequence exchange or copying between terminal regions. The subtelomeric sequences fall into two classes. Seventeen of the chromosome ends terminate with the Y' repeat, while 15 end with the 800-nt "X2" repeats just adjacent to the telomerase simple repeats. The just-subterminal repeats are very similar to each other except that chromosome 1 right end is more divergent.

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Additional Information:Copyright © 1998 by The National Academy of Sciences. This paper was presented at the colloquium "Computational Biomolecular Science," organized by Russell Doolittle, J. Andrew McCammon, and Peter G. Wolynes, held September 11-13, 1997, sponsored by the National Academy of Sciences at the Arnold and Mabel Beckman Center in Irvine, CA. The yeast chromosomal sequences were obtained from the Stanford SGD Thanks to Ed Louis for preprints. Johnny Williams prepared useful software in Perl language. This work was supported by National Institutes of Health grants.
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Subject Keywords:Saccharomyces cerevisiae; inverted recombination; sequence exchange; telomeres; Y' and X2 repeats
Issue or Number:11
PubMed Central ID:PMC34494
Record Number:CaltechAUTHORS:BRIpnas98b
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9874
Deposited By: Archive Administrator
Deposited On:25 Mar 2008
Last Modified:03 Oct 2019 00:04

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