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Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance

DePas, W. and Bergkessel, M. and Newman, D. K. (2019) Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance. Pediatric Pulmonology, 54 (S2). S310. ISSN 8755-6863. https://resolver.caltech.edu/CaltechAUTHORS:20190926-103130771

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Abstract

The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/ppul.22495DOIAbstracts
ORCID:
AuthorORCID
Bergkessel, M.0000-0002-4530-1224
Newman, D. K.0000-0003-1647-1918
Additional Information:© 2019 Wiley Periodicals, Inc. First published: 05 September 2019. Supported by the Cystic Fibrosis Foundation and the National Institutes of Health.
Funders:
Funding AgencyGrant Number
Cystic Fibrosis FoundationUNSPECIFIED
NIHUNSPECIFIED
Issue or Number:S2
Record Number:CaltechAUTHORS:20190926-103130771
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190926-103130771
Official Citation:(2019), Poster Session. Pediatr Pulmonol, 54: S155-S480. doi:10.1002/ppul.22495
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:98873
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2019 18:28
Last Modified:09 Mar 2020 13:18

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